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    Millimeter-Deep Detection of Single Shortwave-Infrared-Emitting Polymer Dots through Turbid Media

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    milideep.pdf
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    Description:
    Accepted manuscript
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    Type
    Article
    Authors
    Piwonski, Hubert Marek cc
    Wang, Yang cc
    Li, Wei
    Michinobu, Tsuyoshi cc
    Habuchi, Satoshi cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    KAUST Grant Number
    OSR-2016-2967-CRG5
    Date
    2020-11-18
    Embargo End Date
    2021-11-18
    Submitted Date
    2020-09-10
    Permanent link to this record
    http://hdl.handle.net/10754/666078
    
    Metadata
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    Abstract
    Fluorescence imaging at longer wavelengths, especially in the shortwave-infrared (SWIR: 1000-1700 nm) region, leads to a substantial decrease in light attenuation, scattering, and background autofluorescence, thereby enabling enhanced penetration into biological tissues. The limited selection of fluorescent probes is a major bottleneck in SWIR fluorescence imaging. Here, we develop SWIR-emitting nanoparticles composed of donor-acceptor-type conjugated polymers. The bright SWIR fluorescence of the polymer dots (primarily attributable to their large absorption cross-section and high fluorescence saturation intensity (as high as 113 kW·cm-2)) enables the unprecedented detection of single particles as small as 14 nm through millimeter-thick turbid media. Unlike most SWIR-emitting nanomaterials, which have an excited-state lifetime in the range of microseconds to milliseconds, our polymer dots exhibit a subnanosecond excited-state lifetime. These characteristics enable us to demonstrate new time-gated single-particle imaging with a high signal-to-background ratio. These findings expand the range of potential applications of single-particle deep-tissue imaging.
    Citation
    Piwoński, H., Wang, Y., Li, W., Michinobu, T., & Habuchi, S. (2020). Millimeter-Deep Detection of Single Shortwave-Infrared-Emitting Polymer Dots through Turbid Media. Nano Letters. doi:10.1021/acs.nanolett.0c03675
    Sponsors
    This study was supported by King Abdullah University of Science and Technology (KAUST) and the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-2967-CRG5.
    Publisher
    American Chemical Society (ACS)
    Journal
    Nano Letters
    DOI
    10.1021/acs.nanolett.0c03675
    PubMed ID
    33206524
    Additional Links
    https://pubs.acs.org/doi/10.1021/acs.nanolett.0c03675
    ae974a485f413a2113503eed53cd6c53
    10.1021/acs.nanolett.0c03675
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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