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    A new approach for quantifying epigenetic landscapes.

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    J. Biol. Chem.-2020-Fischle-15838-9.pdf
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    Type
    Article
    Authors
    Fischle, Wolfgang cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2020-11-20
    Online Publication Date
    2020-11-20
    Print Publication Date
    2020-11-20
    Embargo End Date
    2021-11-21
    Permanent link to this record
    http://hdl.handle.net/10754/666076
    
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    Abstract
    ChIP-Seq is a widespread experimental method for determining the global enrichment of chromatin modifications and genome-associated factors. Whereas it is straightforward to compare the relative genomic distribution of these epigenetic features, researchers have also made efforts to compare their signal strength using external references for normalization. New work now suggests that these "spike-ins" could lead to inaccurate conclusions due to intrinsic issues of the methodology and instead calls for new criteria of experimental reporting that may permit internal standardization when certain parameters are fulfilled.
    Citation
    Fischle, W. (2020). A new approach for quantifying epigenetic landscapes. Journal of Biological Chemistry, 295(47), 15838–15839. doi:10.1074/jbc.h120.016430
    Publisher
    American Society for Biochemistry & Molecular Biology (ASBMB)
    Journal
    Journal of Biological Chemistry
    DOI
    10.1074/jbc.h120.016430
    PubMed ID
    33219165
    Additional Links
    http://www.jbc.org/lookup/doi/10.1074/jbc.H120.016430
    ae974a485f413a2113503eed53cd6c53
    10.1074/jbc.h120.016430
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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