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dc.contributor.authorYao, Ying
dc.contributor.authorZia, Asima
dc.contributor.authorNeumann, Ralf Stefan
dc.contributor.authorPavlovic, Milena
dc.contributor.authorBalaban, Gabriel
dc.contributor.authorLundin, Knut E A
dc.contributor.authorSandve, Geir Kjetil
dc.contributor.authorQiao, Shuo-Wang
dc.date.accessioned2020-11-18T11:33:44Z
dc.date.available2020-11-18T11:33:44Z
dc.date.issued2020-11-13
dc.date.submitted2020-06-04
dc.identifier.citationYao, Y., Zia, A., Neumann, R. S., Pavlovic, M., Balaban, G., Lundin, K. E. A., … Qiao, S.-W. (2020). T cell receptor repertoire as a potential diagnostic marker for celiac disease. Clinical Immunology, 108621. doi:10.1016/j.clim.2020.108621
dc.identifier.issn1521-6616
dc.identifier.pmid33197618
dc.identifier.doi10.1016/j.clim.2020.108621
dc.identifier.urihttp://hdl.handle.net/10754/666015
dc.description.abstractAn individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.
dc.description.sponsorshipThe authors would like to thank Shiva Dahal-Koirala, Louise F Risnes and Ludvig M Sollid for access to the reference TCR database; and Victor Greiff for helpful comments and suggestions that improved the data processing.
dc.description.sponsorshipThis work is funded by Research Council of Norway (project 179573/V40 through the Centre of Excellence funding scheme and project 233885), and grants from the Stiftelsen Kristian Gerhard Jebsen (SKGJ-MED-017).
dc.publisherElsevier BV
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1521661620307816
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Clinical immunology (Orlando, Fla.). Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical immunology (Orlando, Fla.), [, , (2020-11-16)] DOI: 10.1016/j.clim.2020.108621 . © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleT cell receptor repertoire as a potential diagnostic marker for celiac disease.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalClinical Immunology
dc.rights.embargodate2021-11-16
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Immunology, Institute of Clinical Medicine, University of Oslo, Norway.
dc.contributor.institutionK.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Norway.
dc.contributor.institutionDepartment of Informatics, University of Oslo, Norway.
dc.identifier.pages108621
kaust.personZia, Asima
dc.date.accepted2020-11-07
refterms.dateFOA2020-11-18T11:43:25Z
dc.date.published-online2020-11-13
dc.date.published-print2021-01


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