T cell receptor repertoire as a potential diagnostic marker for celiac disease.
Type
ArticleAuthors
Yao, YingZia, Asima
Neumann, Ralf Stefan
Pavlovic, Milena
Balaban, Gabriel
Lundin, Knut E A
Sandve, Geir Kjetil
Qiao, Shuo-Wang
Date
2020-11-13Online Publication Date
2020-11-13Print Publication Date
2021-01Submitted Date
2020-06-04Permanent link to this record
http://hdl.handle.net/10754/666015Metadata
Show full item recordAbstract
An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.Citation
Yao, Y., Zia, A., Neumann, R. S., Pavlovic, M., Balaban, G., Lundin, K. E. A., … Qiao, S.-W. (2020). T cell receptor repertoire as a potential diagnostic marker for celiac disease. Clinical Immunology, 108621. doi:10.1016/j.clim.2020.108621Sponsors
The authors would like to thank Shiva Dahal-Koirala, Louise F Risnes and Ludvig M Sollid for access to the reference TCR database; and Victor Greiff for helpful comments and suggestions that improved the data processing.This work is funded by Research Council of Norway (project 179573/V40 through the Centre of Excellence funding scheme and project 233885), and grants from the Stiftelsen Kristian Gerhard Jebsen (SKGJ-MED-017).