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    T cell receptor repertoire as a potential diagnostic marker for celiac disease.

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    Thumbnail
    Name:
    T cell receptors.pdf
    Size:
    1.768Mb
    Format:
    PDF
    Description:
    Accepted manuscript
    Embargo End Date:
    2021-11-16
    Download
    Type
    Article
    Authors
    Yao, Ying
    Zia, Asima cc
    Neumann, Ralf Stefan
    Pavlovic, Milena
    Balaban, Gabriel
    Lundin, Knut E A
    Sandve, Geir Kjetil
    Qiao, Shuo-Wang
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2020-11-16
    Embargo End Date
    2021-11-16
    Submitted Date
    2020-06-04
    Permanent link to this record
    http://hdl.handle.net/10754/666015
    
    Metadata
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    Abstract
    An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.
    Citation
    Yao, Y., Zia, A., Neumann, R. S., Pavlovic, M., Balaban, G., Lundin, K. E. A., … Qiao, S.-W. (2020). T cell receptor repertoire as a potential diagnostic marker for celiac disease. Clinical Immunology, 108621. doi:10.1016/j.clim.2020.108621
    Sponsors
    The authors would like to thank Shiva Dahal-Koirala, Louise F Risnes and Ludvig M Sollid for access to the reference TCR database; and Victor Greiff for helpful comments and suggestions that improved the data processing.
    This work is funded by Research Council of Norway (project 179573/V40 through the Centre of Excellence funding scheme and project 233885), and grants from the Stiftelsen Kristian Gerhard Jebsen (SKGJ-MED-017).
    Publisher
    Elsevier BV
    Journal
    Clinical immunology (Orlando, Fla.)
    DOI
    10.1016/j.clim.2020.108621
    PubMed ID
    33197618
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S1521661620307816
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clim.2020.108621
    Scopus Count
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    Articles; Biological and Environmental Sciences and Engineering (BESE) Division

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