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dc.contributor.authorAwad, Hoyam
dc.contributor.authorGadalla, Amal A H
dc.contributor.authorPostigo, Milagros
dc.contributor.authorAl-Hamidhi, Salama
dc.contributor.authorTageldin, Mohammed H
dc.contributor.authorSkariah, Sini
dc.contributor.authorSultan, Ali A
dc.contributor.authorJohnson, Eugene H
dc.contributor.authorShiels, Brian
dc.contributor.authorPain, Arnab
dc.contributor.authorThompson, Joanne
dc.contributor.authorBabiker, Hamza A
dc.date.accessioned2020-11-16T10:52:27Z
dc.date.available2020-11-16T10:52:27Z
dc.date.issued2020-11-13
dc.date.submitted2019-12-24
dc.identifier.citationAwad, H., Gadalla, A. A. H., Postigo, M., Al-Hamidhi, S., Tageldin, M. H., Skariah, S., … Babiker, H. A. (2020). Dynamics and within-host interaction of Theileria lestoquardi and T. ovis among naive sheep in Oman. Scientific Reports, 10(1). doi:10.1038/s41598-020-76844-2
dc.identifier.issn2045-2322
dc.identifier.pmid33188233
dc.identifier.doi10.1038/s41598-020-76844-2
dc.identifier.urihttp://hdl.handle.net/10754/665961
dc.description.abstractMixed species infections of Theileria spp. are common in nature. Experimental and epidemiological data suggest that mixed species infections elicit cross-immunity that can modulate pathogenicity and disease burden at the population level. The present study examined within-host interactions, over a period of 13 months during natural infections with two Theileria spp., pathogenic (T. lestoquardi) and non-pathogenic (T. ovis), amongst a cohort of naive sheep in Oman. In the first two months after exposure to infection, a high rate of mortality was seen among sheep infected with T. lestoquardi alone. However, subsequently mixed-infections of T. lestoquardi and T. ovis prevailed, and no further death occurred. The overall densities of both parasite species were significantly higher as single infection vs mixed infection and the higher relative density of pathogenic T. lestoquardi indicated a competitive advantage over T. ovis in mixed infection. The density of both species fluctuated significantly over time, with no difference in density between the very hot (May to August) and warm season (September to April). A high degree of genotype multiplicity was seen among T. lestoquardi infections, which increased with rising parasite density. Our results illustrate a potential competitive interaction between the two ovine Theileria spp., and a substantial reduction in the risk of mortality in mixed parasite infections, indicating that T. ovis confers heterologous protection against lethal T. lestoquardi infection.
dc.description.sponsorshipWe are grateful to the farmers and the staff of the Ministry of Agriculture and Fisheries, Oman, for their support with field surveys. We appreciate the support of the technical staff of the Biochemistry Department, Sultan Qaboos University, Oman. This research is supported by Gulf States Cooperation Council grant (GCC)CL/SQU-GCC/17/01.
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nature.com/articles/s41598-020-76844-2
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDynamics and within-host interaction of Theileria lestoquardi and T. ovis among naive sheep in Oman.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentPathogen Genomics Laboratory
dc.identifier.journalScientific reports
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, AlKhoud 123, Muscat, Oman.
dc.contributor.institutionDivision of Population Medicine, School of Medicine, College of Biomedical Sciences, Cardif University, Cardif, UK. .
dc.contributor.institutionDepartment of Biology, College of Science, Sultan Qaboos University, Muscat, Oman.
dc.contributor.institutionCollege of Agriculture and Marine Sciences, Sultan Qaboos University, Muscat, Oman.
dc.contributor.institutionDepartment of Microbiology and Immunology, Weill Cornell Medicine ‑ Qatar, Cornell University, Qatar Foundation, Doha, Qatar.
dc.contributor.institutionGI‑CoRE, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
dc.contributor.institutionInstitute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
dc.identifier.volume10
dc.identifier.issue1
kaust.personPain, Arnab
dc.date.accepted2020-10-22
refterms.dateFOA2020-11-16T10:53:36Z
dc.date.published-online2020-11-13
dc.date.published-print2020-12


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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.