Three-dimensionally two-photon lithography realized vascular grafts.
KAUST DepartmentPhysical Science and Engineering (PSE) Division
KAUST Grant NumberOCRF-2016-CRG5
Online Publication Date2021-03-01
Print Publication Date2021-05-01
Permanent link to this recordhttp://hdl.handle.net/10754/665941
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AbstractGeneration of artifical vascular grafts (TEVG) as blood vessel substitutes is a primary challenge in biomaterial and tissue engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behaviour to withstand the pressure exerted by blood flow.
CitationLimongi, T., Brigo, L., Tirinato, L., Pagliari, F., Gandin, A., Contessotto, P., … Brusatin, G. (2020). Three-dimensionally two-photon lithography realized vascular grafts. Biomedical Materials. doi:10.1088/1748-605x/abca4b
SponsorsG. B. acknowledges the University of Padova for financial support of through "Finanziamento per le attrezzature scientifiche finalizzate alla ricerca - Bando 2013" and SID project “3D Engineered Biopolymers Micro Fabrication by Two-Photon Laser Additive Manufacturing”. A. G. acknowledges financial support from the KAUST funding through CRG5 project OSR award #: OCRF-2016-CRG5.
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