Three-dimensionally two-photon lithography realized vascular grafts.

License
https://creativecommons.org/licences/by/3.0

Type
Article

Authors
Limongi, Tania
Brigo, Laura
Tirinato, Luca
Pagliari, Francesca
Gandin, Alessandro
Contessotto, Paolo
Giugni, Andrea
Brusatin, Giovanna

KAUST Department
Physical Science and Engineering (PSE) Division

KAUST Grant Number
OCRF-2016-CRG5

Online Publication Date
2021-03-01

Print Publication Date
2021-05-01

Date
2021-03-01

Submitted Date
2020-10-30

Abstract
Generation of artifical vascular grafts (TEVG) as blood vessel substitutes is a primary challenge in biomaterial and tissue engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behaviour to withstand the pressure exerted by blood flow.

Citation
Limongi, T., Brigo, L., Tirinato, L., Pagliari, F., Gandin, A., Contessotto, P., … Brusatin, G. (2020). Three-dimensionally two-photon lithography realized vascular grafts. Biomedical Materials. doi:10.1088/1748-605x/abca4b

Acknowledgements
G. B. acknowledges the University of Padova for financial support of through "Finanziamento per le attrezzature scientifiche finalizzate alla ricerca - Bando 2013" and SID project “3D Engineered Biopolymers Micro Fabrication by Two-Photon Laser Additive Manufacturing”. A. G. acknowledges financial support from the KAUST funding through CRG5 project OSR award #: OCRF-2016-CRG5.

Publisher
IOP Publishing

Journal
Biomedical Materials

DOI
10.1088/1748-605x/abca4b

PubMed ID
33186926

Additional Links
https://iopscience.iop.org/article/10.1088/1748-605X/abca4b

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