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“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine

dc.contributor.authorAbdelrahman, Sherin
dc.contributor.authorAlghrably, Mawadda
dc.contributor.authorLachowicz, Joanna Izabela
dc.contributor.authorEmwas, Abdul-Hamid M.
dc.contributor.authorHauser, Charlotte
dc.contributor.authorJaremko, Mariusz
dc.date.accessioned2020-11-12T05:06:30Z
dc.date.available2020-11-12T05:06:30Z
dc.date.issued2020-11-11
dc.date.submitted2020-09-18
dc.identifier.citationAbdelrahman, S., Alghrably, M., Lachowicz, J. I., Emwas, A.-H., Hauser, C. A. E., & Jaremko, M. (2020). “What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine. Molecules, 25(22), 5245. doi:10.3390/molecules25225245
dc.identifier.issn1420-3049
dc.identifier.doi10.3390/molecules25225245
dc.identifier.urihttp://hdl.handle.net/10754/665915
dc.description.abstractAmyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans. Although the disease pathogenies have been associated with protein aggregation, the mechanisms and factors that lead to protein aggregation are not completely understood. Paradoxically, unique characteristics of amyloids provide new opportunities for engineering innovative materials with biomedical applications. In this review, we discuss not only outstanding advances in biomedical applications of amyloid peptides, but also the mechanism of amyloid aggregation, factors affecting the process, and core sequences driving the aggregation. We aim with this review to provide a useful manual for those who engineer amyloids for innovative medicine solutions.
dc.description.sponsorshipM.J., and M.A. would like to thank the King Abdullah University of Science and Technology (KAUST) for the financial support.
dc.publisherMDPI AG
dc.relation.urlhttps://www.mdpi.com/1420-3049/25/22/5245
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentNMR
dc.identifier.journalMolecules
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Medical Sciences and Public Health, University of Cagliari, Policlinico Universitario, I-09042 Monserrato, Italy.
dc.identifier.volume25
dc.identifier.issue22
dc.identifier.pages5245
kaust.personAbdelrahman, Sherin
kaust.personAlghrably, Mawadda
kaust.personEmwas, Abdul-Hamid M.
kaust.personHauser, Charlotte
kaust.personJaremko, Mariusz
dc.date.accepted2020-10-27
refterms.dateFOA2020-11-12T05:12:35Z


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.