“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine
Type
ArticleAuthors
Abdelrahman, Sherin
Alghrably, Mawadda
Lachowicz, Joanna Izabela

Emwas, Abdul-Hamid M.

Hauser, Charlotte

Jaremko, Mariusz

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computational Bioscience Research Center (CBRC)
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
NMR
Date
2020-11-11Submitted Date
2020-09-18Permanent link to this record
http://hdl.handle.net/10754/665915
Metadata
Show full item recordAbstract
Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans. Although the disease pathogenies have been associated with protein aggregation, the mechanisms and factors that lead to protein aggregation are not completely understood. Paradoxically, unique characteristics of amyloids provide new opportunities for engineering innovative materials with biomedical applications. In this review, we discuss not only outstanding advances in biomedical applications of amyloid peptides, but also the mechanism of amyloid aggregation, factors affecting the process, and core sequences driving the aggregation. We aim with this review to provide a useful manual for those who engineer amyloids for innovative medicine solutions.Citation
Abdelrahman, S., Alghrably, M., Lachowicz, J. I., Emwas, A.-H., Hauser, C. A. E., & Jaremko, M. (2020). “What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine. Molecules, 25(22), 5245. doi:10.3390/molecules25225245Sponsors
M.J., and M.A. would like to thank the King Abdullah University of Science and Technology (KAUST) for the financial support.Publisher
MDPI AGJournal
MoleculesAdditional Links
https://www.mdpi.com/1420-3049/25/22/5245ae974a485f413a2113503eed53cd6c53
10.3390/molecules25225245
Scopus Count
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