“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine

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Type
Article
Authors
Abdelrahman, Sherin
Alghrably, Mawadda
Lachowicz, Joanna Izabela cc
Emwas, Abdul-Hamid M. cc
Hauser, Charlotte cc
Jaremko, Mariusz cc
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Computational Bioscience Research Center (CBRC)
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
NMR
Date
2020-11-11
Submitted Date
2020-09-18
Permanent link to this record
http://hdl.handle.net/10754/665915

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Abstract
Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans. Although the disease pathogenies have been associated with protein aggregation, the mechanisms and factors that lead to protein aggregation are not completely understood. Paradoxically, unique characteristics of amyloids provide new opportunities for engineering innovative materials with biomedical applications. In this review, we discuss not only outstanding advances in biomedical applications of amyloid peptides, but also the mechanism of amyloid aggregation, factors affecting the process, and core sequences driving the aggregation. We aim with this review to provide a useful manual for those who engineer amyloids for innovative medicine solutions.
Citation
Abdelrahman, S., Alghrably, M., Lachowicz, J. I., Emwas, A.-H., Hauser, C. A. E., & Jaremko, M. (2020). “What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine. Molecules, 25(22), 5245. doi:10.3390/molecules25225245
Sponsors
M.J., and M.A. would like to thank the King Abdullah University of Science and Technology (KAUST) for the financial support.
Publisher
MDPI AG
Journal
Molecules
DOI
10.3390/molecules25225245
Additional Links
https://www.mdpi.com/1420-3049/25/22/5245
Collections
Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.