“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine

Abstract
Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans. Although the disease pathogenies have been associated with protein aggregation, the mechanisms and factors that lead to protein aggregation are not completely understood. Paradoxically, unique characteristics of amyloids provide new opportunities for engineering innovative materials with biomedical applications. In this review, we discuss not only outstanding advances in biomedical applications of amyloid peptides, but also the mechanism of amyloid aggregation, factors affecting the process, and core sequences driving the aggregation. We aim with this review to provide a useful manual for those who engineer amyloids for innovative medicine solutions.

Citation
Abdelrahman, S., Alghrably, M., Lachowicz, J. I., Emwas, A.-H., Hauser, C. A. E., & Jaremko, M. (2020). “What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine. Molecules, 25(22), 5245. doi:10.3390/molecules25225245

Acknowledgements
M.J., and M.A. would like to thank the King Abdullah University of Science and Technology (KAUST) for the financial support.

Publisher
MDPI AG

Journal
Molecules

DOI
10.3390/molecules25225245

Additional Links
https://www.mdpi.com/1420-3049/25/22/5245

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