Show simple item record

dc.contributor.authorDutta, Cintya Nirvana
dc.contributor.authorDouglas, Pamela K.
dc.contributor.authorOmbao, Hernando
dc.date.accessioned2020-11-02T13:59:18Z
dc.date.available2020-11-02T13:59:18Z
dc.date.issued2020-10-26
dc.identifier.urihttp://hdl.handle.net/10754/665773
dc.description.abstractAlterations in structural brain laterality are reported in attention-deficit/hyperactivity disorder (ADHD). However, few studies examined differences within presentations of ADHD. We investigate asymmetry index (AI) across 13 subcortical and 33 cortical regions from anatomical metrics of volume, surface area, and thickness. Structural T1-weighted MRI data were obtained from youths with inattentive (n = 64) and combined (n = 51) presentations, and aged-matched controls (n = 298). We used a linear mixed effect model that accounts for data site heterogeneity, while studying associations between AI and covariates of presentation and age. Our paper contributes to the functional results seen among ADHD presentations evidencing disrupted connectivity in motor networks from ADHD-C and cingulo-frontal networks from ADHD-I, as well as new findings in the temporal cortex and default mode subnetworks. Age patterns of structural asymmetries vary with presentation type. Linear mixed effects model is a practical tool for characterizing associations between brain asymmetries, diagnosis, and neurodevelopment.
dc.description.sponsorshipWe appreciate the efforts of The Neuro Bureau and Virginia Tech’s ARC team for providing the ADHD-200 preprocessed data repository. We give profound thanks to the King Abdullah University of Science and Technology for providing our team with the baseline funds to conduct this work. Last, we thank the KAUST Biostatistics Group and Dr. Aritra Dutta for their feedback and suggestions. The authors acknowledge the support provided in part by the NARSAD Young Investigator Grant and the K01 NIH (1MH110645).
dc.publisherarXiv
dc.relation.urlhttps://arxiv.org/pdf/2010.13458
dc.rightsArchived with thanks to arXiv
dc.titleStructural Brain Asymmetries in Youths with Combined and Inattentive Presentations of Attention Deficit Hyperactivity Disorder
dc.typePreprint
dc.contributor.departmentBiostatistics Group
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentStatistics Program
dc.eprint.versionPre-print
dc.contributor.institutionSMST; Department of Computer Science; University of Central Florida, USA.
dc.contributor.institutionPsychiatry & Biobehavioral Medicine, University of California, Los Angeles, USA.
dc.identifier.arxivid2010.13458
kaust.personDutta, Cintya Nirvana
kaust.personOmbao, Hernando
refterms.dateFOA2020-11-02T13:59:42Z
kaust.acknowledged.supportUnitbase line funds


Files in this item

Thumbnail
Name:
Preprintfile1.pdf
Size:
1.802Mb
Format:
PDF
Description:
Pre-print

This item appears in the following Collection(s)

Show simple item record