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    Ultrashort Peptide Theranostic Nanoparticles by Microfluidic-Assisted Rapid Solvent Exchange

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    Name:
    IEEE Ni et al Theranostic nanoparticles.pdf
    Size:
    9.089Mb
    Format:
    PDF
    Description:
    Accepted manuscript
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    Type
    Article
    Authors
    Ni, Ming
    Tresset, Guillaume
    Iliescu, Ciprian cc
    Hauser, Charlotte cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Date
    2020-07-03
    Online Publication Date
    2020-07-03
    Print Publication Date
    2020-10
    Submitted Date
    2020-05-08
    Permanent link to this record
    http://hdl.handle.net/10754/665647
    
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    Abstract
    Ultrashort peptides (USPs), composed of three to seven amino acids, can self-assemble into nanofibers in pure water. Here, using hydrodynamic focusing and a solvent exchange method on a microfluidic setup, we convert these nanofibers into globular nanoparticles with excellent dimensional control and polydispersity. Thanks to USP nanocarriers' structure, different drugs can be loaded. We used Curcumin as a model drug to evaluate the performance of USP nanocarriers as a novel drug delivery vehicle. These nanoparticles can efficiently cross the cell membrane and possess nonlinear optical properties. Therefore, we envisage USP nanoparticles as promising future theranostic nanocarriers.
    Citation
    Ni, M., Tresset, G., Iliescu, C., & Hauser, C. A. E. (2020). Ultrashort Peptide Theranostic Nanoparticles by Microfluidic-Assisted Rapid Solvent Exchange. IEEE Transactions on NanoBioscience, 19(4), 627–632. doi:10.1109/tnb.2020.3007103
    Publisher
    Institute of Electrical and Electronics Engineers (IEEE)
    Journal
    IEEE Transactions on Nanobioscience
    DOI
    10.1109/TNB.2020.3007103
    Additional Links
    https://ieeexplore.ieee.org/document/9133196/
    ae974a485f413a2113503eed53cd6c53
    10.1109/TNB.2020.3007103
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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