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    NMR as a “Gold Standard” Method in Drug Design and Discovery

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    molecules-25-04597.pdf
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    Type
    Article
    Authors
    Emwas, Abdul-Hamid M. cc
    Szczepski, Kacper
    Gabriel Poulson, Benjamin
    Chandra, Kousik
    mcKay, ryan
    Dhahri, Manel cc
    Alahmari, Fatimah
    Jaremko, Lukasz cc
    Lachowicz, Joanna Izabela cc
    Jaremko, Mariusz cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    NMR
    Date
    2020-10-09
    Submitted Date
    2020-09-22
    Permanent link to this record
    http://hdl.handle.net/10754/665526
    
    Metadata
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    Abstract
    Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance. Cancer cells also change genetically, and current therapeutic techniques may be (or may become) ineffective in many cases. The pathology of many neurological diseases remains an enigma, and the exact etiology and underlying mechanisms are still largely unknown. Viral infections spread and develop much more quickly than does the corresponding research needed to prevent and combat these infections; the present and most relevant outbreak of SARS-CoV-2, which originated in Wuhan, China, illustrates the critical and immediate need to improve drug design and development techniques. Modern day drug discovery is a time-consuming, expensive process. Each new drug takes in excess of 10 years to develop and costs on average more than a billion US dollars. This demonstrates the need of a complete redesign or novel strategies. Nuclear Magnetic Resonance (NMR) has played a critical role in drug discovery ever since its introduction several decades ago. In just three decades, NMR has become a “gold standard” platform technology in medical and pharmacology studies. In this review, we present the major applications of NMR spectroscopy in medical drug discovery and development. The basic concepts, theories, and applications of the most commonly used NMR techniques are presented. We also summarize the advantages and limitations of the primary NMR methods in drug development.
    Citation
    Emwas, A.-H., Szczepski, K., Poulson, B. G., Chandra, K., McKay, R. T., Dhahri, M., … Jaremko, M. (2020). NMR as a “Gold Standard” Method in Drug Design and Discovery. Molecules, 25(20), 4597. doi:10.3390/molecules25204597
    Sponsors
    The authors would like to thank King Abdullah University of Science and Technology (KAUST) for financial support.
    Publisher
    MDPI AG
    Journal
    Molecules
    DOI
    10.3390/molecules25204597
    Additional Links
    https://www.mdpi.com/1420-3049/25/20/4597
    https://www.researchgate.net/publication/344569569_NMR_as_a_Gold_Standard_Method_in_Drug_Design_and_Discovery
    ae974a485f413a2113503eed53cd6c53
    10.3390/molecules25204597
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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