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dc.contributor.authorLachowicz, Joanna Izabela
dc.contributor.authorSzczepski, Kacper
dc.contributor.authorScano, Alessandra
dc.contributor.authorCasu, Cinzia
dc.contributor.authorFais, Sara
dc.contributor.authorOrrù, Germano
dc.contributor.authorPisano, Barbara
dc.contributor.authorPiras, Monica
dc.contributor.authorJaremko, Mariusz
dc.date.accessioned2020-10-08T05:33:49Z
dc.date.available2020-10-08T05:33:49Z
dc.date.issued2020-10-05
dc.date.submitted2020-08-31
dc.identifier.citationLachowicz, J. I., Szczepski, K., Scano, A., Casu, C., Fais, S., Orrù, G., … Jaremko, M. (2020). The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides. International Journal of Molecular Sciences, 21(19), 7349. doi:10.3390/ijms21197349
dc.identifier.issn1422-0067
dc.identifier.doi10.3390/ijms21197349
dc.identifier.urihttp://hdl.handle.net/10754/665486
dc.description.abstractHealth-care systems that develop rapidly and efficiently may increase the lifespan of humans. Nevertheless, the older population is more fragile, and is at an increased risk of disease development. A concurrently growing number of surgeries and transplantations have caused antibiotics to be used much more frequently, and for much longer periods of time, which in turn increases microbial resistance. In 1945, Fleming warned against the abuse of antibiotics in his Nobel lecture: “The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant”. After 70 years, we are witnessing the fulfilment of Fleming’s prophecy, as more than 700,000 people die each year due to drug-resistant diseases. Naturally occurring antimicrobial peptides protect all living matter against bacteria, and now different peptidomimetic strategies to engineer innovative antibiotics are being developed to defend humans against bacterial infections.
dc.description.sponsorshipK.S. and M.J. would like to thank King Abdullah University of Science and Technology (KAUST) for financial support.
dc.publisherMDPI AG
dc.relation.urlhttps://www.mdpi.com/1422-0067/21/19/7349
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Best Peptidomimetic Strategies to Undercover Antibacterial Peptides
dc.typeArticle
dc.contributor.departmentBioscience
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalInternational Journal of Molecular Sciences
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
dc.contributor.institutionDepartment of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, 09124 Cagliari, Italy.
dc.identifier.volume21
dc.identifier.issue19
dc.identifier.pages7349
kaust.personSzczepski, Kacper
kaust.personJaremko, Mariusz
dc.date.accepted2020-09-25
refterms.dateFOA2020-10-08T05:34:43Z


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
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