The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides
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ArticleAuthors
Lachowicz, Joanna IzabelaSzczepski, Kacper
Scano, Alessandra
Casu, Cinzia

Fais, Sara
Orrù, Germano

Pisano, Barbara

Piras, Monica
Jaremko, Mariusz

KAUST Department
BioscienceBiological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Date
2020-10-05Submitted Date
2020-08-31Permanent link to this record
http://hdl.handle.net/10754/665486
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Health-care systems that develop rapidly and efficiently may increase the lifespan of humans. Nevertheless, the older population is more fragile, and is at an increased risk of disease development. A concurrently growing number of surgeries and transplantations have caused antibiotics to be used much more frequently, and for much longer periods of time, which in turn increases microbial resistance. In 1945, Fleming warned against the abuse of antibiotics in his Nobel lecture: “The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant”. After 70 years, we are witnessing the fulfilment of Fleming’s prophecy, as more than 700,000 people die each year due to drug-resistant diseases. Naturally occurring antimicrobial peptides protect all living matter against bacteria, and now different peptidomimetic strategies to engineer innovative antibiotics are being developed to defend humans against bacterial infections.Citation
Lachowicz, J. I., Szczepski, K., Scano, A., Casu, C., Fais, S., Orrù, G., … Jaremko, M. (2020). The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides. International Journal of Molecular Sciences, 21(19), 7349. doi:10.3390/ijms21197349Sponsors
K.S. and M.J. would like to thank King Abdullah University of Science and Technology (KAUST) for financial support.Publisher
MDPI AGAdditional Links
https://www.mdpi.com/1422-0067/21/19/7349ae974a485f413a2113503eed53cd6c53
10.3390/ijms21197349
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