Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes
Type
ArticleAuthors
Zaric, Bozidarka L.Radovanovic, Jelena N.
Gluvic, Zoran
Stewart, Alan J.
Essack, Magbubah

Motwalli, Olaa
Gojobori, Takashi

Isenovic, Esma R.
KAUST Department
Computational Bioscience Research Center (CBRC)Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Bioscience Program
Biological and Environmental Sciences and Engineering (BESE) Division
KAUST Grant Number
OSR#4129 (EI and TGFCC/1/1976-17-01
Date
2020-09-28Submitted Date
2020-04-14Permanent link to this record
http://hdl.handle.net/10754/665422
Metadata
Show full item recordAbstract
Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, and glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases 1 and 2 are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.Citation
Zaric, B. L., Radovanovic, J. N., Gluvic, Z., Stewart, A. J., Essack, M., Motwalli, O., … Isenovic, E. R. (2020). Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes. Frontiers in Immunology, 11. doi:10.3389/fimmu.2020.551758Sponsors
This work is part of the collaboration between the Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Saudi Arabia. The manuscript has been professionally corrected by a scientific editor from the scientific editing and translation company European Training Academy, Belgrade, Serbia.The research was funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia and by the KAUST grant OSR#4129 (EI and TG). TG was supported by the KAUST Base Research Funds BAS/1/1059-01-01, respectively, while ME was supported by the KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.
Publisher
Frontiers Media SAJournal
Frontiers in ImmunologyAdditional Links
https://www.frontiersin.org/article/10.3389/fimmu.2020.551758/fullae974a485f413a2113503eed53cd6c53
10.3389/fimmu.2020.551758
Scopus Count
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