• Login
    View Item 
    •   Home
    • Research
    • Articles
    • View Item
    •   Home
    • Research
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguideTheses and Dissertations LibguideSubmit an Item

    Statistics

    Display statistics

    A New Synthetic Methodology of Site-Specific Functionalized Polypeptides: Metal-Free, Highly Active and Selective at Room Temperature

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    A new synthetic.pdf
    Size:
    2.285Mb
    Format:
    PDF
    Description:
    Accepted Article
    Download
    Type
    Article
    Authors
    Zhao, Wei
    Lv, Yanfeng
    Li, Ji
    Feng, Zihao
    Ni, Yonghao
    Hadjichristidis, Nikos cc
    KAUST Department
    Chemical Science Program
    KAUST Catalysis Center (KCC)
    Physical Science and Engineering (PSE) Division
    Polymer Synthesis Laboratory
    Date
    2020-11-03
    Online Publication Date
    2020-11-03
    Print Publication Date
    2021-01-11
    Embargo End Date
    2021-09-16
    Submitted Date
    2020-07-06
    Permanent link to this record
    http://hdl.handle.net/10754/665334
    
    Metadata
    Show full item record
    Abstract
    Functionalized polypeptides have attracted tremendous interest in recent years and found many stimulating applications due to their tunable physicochemical characteristics including hydrophilicity and stimuli-responsive behavior. The development of new strategies to produce these polymers without metallic contaminants is crucial for their applications in high-value and sensitive domains, such as biomedical, microelectronic, food packaging and personal beauty care fields. Herein, a highly efficient strategy to access well-defined site-specific functionalized polypeptides is developed by combining Michael reaction with hydrogen-bonding organocatalytic ROP of NCA. A library of chain-end and chain-middle functionalized polypeptides (14 examples) with predesigned molecular weights and low polydispersities are readily prepared with this approach. Specifically, the whole synthetic process is metal-free, fulfilling high activity and selectivity at room temperature.
    Citation
    Zhao, W., Lv, Y., Li, J., Feng, Z., Ni, Y., & Hadjichristidis, N. (2020). A New Synthetic Methodology of Site-Specific Functionalized Polypeptides: Metal-Free, Highly Active and Selective at Room Temperature. Angewandte Chemie International Edition. doi:10.1002/anie.202009316
    Sponsors
    This work is supported by grants from the National Natural Science Foundation of China (No. 21774071) and Natural Science Foundation of Shaanxi University of Science and Technology (No. 2017QNBJ-07). W. Z. thanks the support from the Youth Hundred-Talent Program of Shaanxi Province (No.SXBR9227), the National High-Level Foreign Expert Project (No.GDT20186100425), Biomass Chemistry and Materials Academician Workstation Project in SUST (No.134090002) and Northwest Polytechnic University High-Performance Computing and Development Center. N. H. acknowledges the support of King Abdullah University of Science and Technology.
    Publisher
    Wiley
    Journal
    Angewandte Chemie
    DOI
    10.1002/anie.202009316
    10.1002/ange.202009316
    PubMed ID
    32935922
    Additional Links
    https://onlinelibrary.wiley.com/doi/10.1002/anie.202009316
    ae974a485f413a2113503eed53cd6c53
    10.1002/anie.202009316
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)

    entitlement

    Related articles

    • Fast and selective organocatalytic ring-opening polymerization by fluorinated alcohol without a cocatalyst.
    • Authors: Zhao W, Lv Y, Li J, Feng Z, Ni Y, Hadjichristidis N
    • Issue date: 2019 Aug 9
    • Synthesis and biomedical applications of functional poly(α-hydroxy acids) via ring-opening polymerization of O-carboxyanhydrides.
    • Authors: Yin Q, Yin L, Wang H, Cheng J
    • Issue date: 2015 Jul 21
    • Synthesis and Properties of Mono- or Diamine-Initiated Imidazolium-Based Cationic Polypeptides.
    • Authors: Shi Z, Zhang X, Wang X, Yang F, Yu Z, Ling Y, Lu H, Luan S, Tang H
    • Issue date: 2020 Aug 10
    • A facile glovebox-free strategy to significantly accelerate the syntheses of well-defined polypeptides by N-carboxyanhydride (NCA) ring opening polymerizations.
    • Authors: Zou J, Fan J, He X, Zhang S, Wang H, Wooley KL
    • Issue date: 2013 May 28
    • Thiourea-based bifunctional organocatalysis: supramolecular recognition for living polymerization.
    • Authors: Dove AP, Pratt RC, Lohmeijer BG, Waymouth RM, Hedrick JL
    • Issue date: 2005 Oct 12
    DSpace software copyright © 2002-2023  DuraSpace
    Quick Guide | Contact Us | KAUST University Library
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.