The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

Citation

Scattolin, T., Bortolamiol, E., Palazzolo, S., Caligiuri, I., Perin, T., Canzonieri, V., … Visentin, F. (2020). The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer. Chemical Communications. doi:10.1039/d0cc03883k

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[Dataset]
Scattolin, Thomas, Bortolamiol, Enrica, Palazzolo, Stefano, Caligiuri, Isabella, Perin, Tiziana, Canzonieri, Vincenzo, Demitri, Nicola, Rizzolio, Flavio, Cavallo, Luigi, Dereli, Busra, Mane, Manoj V., Nolan, Steven P., & Visentin, Fabiano. (2020). CCDC 2006223: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/CCDC.CSD.CC25BMW1. DOI: 10.5517/ccdc.csd.cc25bmw1 Handle: 10754/665211

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Articles; Physical Science and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)