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dc.contributor.authorAlam, Intikhab
dc.contributor.authorGasol, Josep M
dc.contributor.authorArold, Stefan T.
dc.contributor.authorGojobori, Takashi
dc.contributor.authorKamau, Allan A
dc.contributor.authorAalismail, Nojood
dc.contributor.authorMartin, Cecilia
dc.contributor.authorMomin, Afaque Ahmad Imtiyaz
dc.contributor.authorAcinas, Silvia G
dc.contributor.authorGuzmán-Vega, Francisco J.
dc.contributor.authorAgusti, Susana R
dc.contributor.authorJamil, Tahira
dc.contributor.authorDuarte, Carlos M.
dc.date.accessioned2020-09-14T12:43:19Z
dc.date.available2020-09-14T12:43:19Z
dc.date.issued2020-09-09
dc.identifier.citationAlam, I., Gasol, J. M., Arold, S. T., Gojobori, T., Kamau, A. A., Aalismail, N., … Duarte, C. M. (2020). Rapid Evolution of Plastic-degrading Enzymes Prevalent in the Global Ocean. doi:10.1101/2020.09.07.285692
dc.identifier.doi10.1101/2020.09.07.285692
dc.identifier.urihttp://hdl.handle.net/10754/665130
dc.description.abstractEstimates of marine plastic stocks, a major threat to marine life, are far lower than expected from exponentially-increasing litter inputs, suggesting important loss factors. These may involve microbial degradation, as the plastic-degrading polyethylene terephthalate enzyme (PETase) has been reported in marine microbial communities. An assessment of 416 metagenomes of planktonic communities across the global ocean identifies 68 oceanic PETase variants (oPETase) that evolved from ancestral enzymes degrading polycyclic aromatic hydrocarbons. Nearly 20 oPETases have predicted efficiencies comparable to those of laboratory-optimized PETases, suggesting strong selective pressures directing the evolution of these enzymes. We found oPETases in 90.1% of samples across all oceans and depths, particularly abundant at 1,000 m depth, with a strong dominance of Pseudomonadales containing putative highly-efficient oPETase variants in the dark ocean. Enzymatic degradation may be removing plastic from the marine environment while providing a carbon source for bathypelagic microbial communities.
dc.publisherCold Spring Harbor Laboratory
dc.relation.urlhttp://biorxiv.org/lookup/doi/10.1101/2020.09.07.285692
dc.rightsArchived with thanks to Cold Spring Harbor Laboratory
dc.titleRapid Evolution of Plastic-degrading Enzymes Prevalent in the Global Ocean
dc.typePreprint
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentMarine Science Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.contributor.departmentStructural Biology and Engineering
dc.eprint.versionPre-print
dc.contributor.institutionDepartament de Biologia Marina i Oceanografia, Institut de Ciències del Mar-CSIC, Pg. Marítim de la Barceloneta 37-49, 08003, Barcelona, Spain.
dc.contributor.institutionCentre de Biochimie Structurale, CNRS, INSERM, Université de Montpellier, 34090 Montpellier, France.
kaust.personAlam, Intikhab
kaust.personArold, Stefan T.
kaust.personGojobori, Takashi
kaust.personKamau, Allan A
kaust.personAalismail, Nojood Adel Ali
kaust.personMartin, Cecilia
kaust.personMomin, Afaque Ahmad Imtiyaz
kaust.personGuzman Vega, Francisco
kaust.personAgusti, Susana R
kaust.personJamil, Tahira
kaust.personDuarte, Carlos M.
kaust.personDuarte, Carlos M.
refterms.dateFOA2020-09-14T12:45:08Z


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