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dc.contributor.authorLimongi, Tania
dc.contributor.authorSusa, Francesca
dc.contributor.authorAllione, Marco
dc.contributor.authorDi Fabrizio, Enzo
dc.date.accessioned2020-09-13T10:04:08Z
dc.date.available2020-09-13T10:04:08Z
dc.date.issued2020-09-08
dc.date.submitted2020-06-30
dc.identifier.citationLimongi, T., Susa, F., Allione, M., & di Fabrizio, E. (2020). Drug Delivery Applications of Three-Dimensional Printed (3DP) Mesoporous Scaffolds. Pharmaceutics, 12(9), 851. doi:10.3390/pharmaceutics12090851
dc.identifier.issn1999-4923
dc.identifier.pmid32911620
dc.identifier.doi10.3390/pharmaceutics12090851
dc.identifier.urihttp://hdl.handle.net/10754/665081
dc.description.abstractMesoporous materials are structures characterized by a well-ordered large pore system with uniform porous dimensions ranging between 2 and 50 nm. Typical samples are zeolite, carbon molecular sieves, porous metal oxides, organic and inorganic porous hybrid and pillared materials, silica clathrate and clathrate hydrates compounds. Improvement in biochemistry and materials science led to the design and implementation of different types of porous materials ranging from rigid to soft two-dimensional (2D) and three-dimensional (3D) skeletons. The present review focuses on the use of three-dimensional printed (3DP) mesoporous scaffolds suitable for a wide range of drug delivery applications, due to their intrinsic high surface area and high pore volume. In the first part, the importance of the porosity of materials employed for drug delivery application was discussed focusing on mesoporous materials. At the end of the introduction, hard and soft templating synthesis for the realization of ordered 2D/3D mesostructured porous materials were described. In the second part, 3DP fabrication techniques, including fused deposition modelling, material jetting as inkjet printing, electron beam melting, selective laser sintering, stereolithography and digital light processing, electrospinning, and two-photon polymerization were described. In the last section, through recent bibliographic research, a wide number of 3D printed mesoporous materials, for in vitro and in vivo drug delivery applications, most of which relate to bone cells and tissues, were presented and summarized in a table in which all the technical and bibliographical details were reported. This review highlights, to a very cross-sectional audience, how the interdisciplinarity of certain branches of knowledge, as those of materials science and nano-microfabrication are, represent a growing valuable aid in the advanced forum for the science and technology of pharmaceutics and biopharmaceutics.
dc.publisherMDPI AG
dc.relation.urlhttps://www.mdpi.com/1999-4923/12/9/851
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDrug Delivery Applications of Three-Dimensional Printed (3DP) Mesoporous Scaffolds
dc.typeArticle
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalPharmaceutics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy.
dc.identifier.volume12
dc.identifier.issue9
dc.identifier.pages851
kaust.personAllione, Marco
dc.date.accepted2020-09-05
refterms.dateFOA2020-09-13T10:05:46Z


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.