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dc.contributor.authorAlghwiri, Alia A
dc.contributor.authorJamali, Fatima
dc.contributor.authorAldughmi, Mayis
dc.contributor.authorKhalil, Hanan
dc.contributor.authorAl-Sharman, Alham
dc.contributor.authorAlhattab, Dana Majed
dc.contributor.authorAl-Radaideh, Ali
dc.contributor.authorAwidi, Abdalla
dc.date.accessioned2020-09-06T13:56:39Z
dc.date.available2020-09-06T13:56:39Z
dc.date.issued2020-08-21
dc.date.submitted2020-07-02
dc.identifier.citationAlghwiri, A. A., Jamali, F., Aldughmi, M., Khalil, H., Al-Sharman, A., Alhattab, D., … Awidi, A. (2020). The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis. Medicine, 99(34), e21646. doi:10.1097/md.0000000000021646
dc.identifier.issn0304-5412
dc.identifier.pmid32846775
dc.identifier.doi10.1097/md.0000000000021646
dc.identifier.urihttp://hdl.handle.net/10754/664959
dc.description.abstractINTRODUCTION:People with multiple sclerosis (PwMS) experience a wide range of disabilities which negatively impact their quality of life (QOL). Several interventions have been used in PwMS such as medication, physical therapy exercises and stem cell therapy to improve their QOL. However, there is a limited evidence on the benefits of combining interventions. The purpose of this study is to explore the effect of combining physical therapy exercises (PTE) and Wharton Jelly mesenchymal stem cell (WJ-MSCs) injections on motor and non-motor symptoms versus each intervention alone in PwMS. METHODS:Sixty PwMS will be allocated to either PTE, WJ-MSCs, or a combined group, followed up for 12 months and examined using a comprehensive battery of measures. Participants in the PTE group will receive 2 sessions per week of a supervised exercise program for 6 months followed by a home exercise program for another 6 months. The WJ-MSCs group will receive 3 WJ-MSCs injections in the first 6 months then they will be encouraged to follow an active life style. The third group will receive both interventions. DISCUSSION:This study will aid in a better understanding of the combined effect of physical therapy and mesenchymal stem cell therapy. The results from this proposed study may reduce disability, improve QOL in PwMS, and consequently, reduce the cost associated with the life-time care of these individuals worldwide. TRIAL REGISTRATION NUMBER:NCT03326505.
dc.description.sponsorshipAuthors would like to thank the CTC personnel, research assistants, and patients for their commitment to this trial.
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.urlhttps://journals.lww.com/10.1097/MD.0000000000021646
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.titleThe effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis: A comparative study.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalMedicine
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Physiotherapy, School of Rehabilitation Sciences
dc.contributor.institutionCell Therapy Center, University of Jordan, Amman, Jordan
dc.contributor.institutionDepartment of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
dc.contributor.institutionDepartment of Medical Imaging, Faculty of Applied Medical Sciences, Hashemite University, Zarqa, Jordan
dc.contributor.institutionSchool of Medicine, University of Jordan, Amman, Jordan
dc.identifier.volume99
dc.identifier.issue34
dc.identifier.pagese21646
kaust.personAlhattab, Dana Majed
dc.date.accepted2020-07-09
dc.identifier.eid2-s2.0-85089987353
refterms.dateFOA2020-09-06T14:01:19Z


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This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.