The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis: A comparative study.
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The effectiveness of a pseudo‐inverse extended Born operator to handle lateral heterogeneity for imaging and velocity analysis applications.pdf
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Alghwiri, Alia AJamali, Fatima
Aldughmi, Mayis
Khalil, Hanan
Al-Sharman, Alham
Alhattab, Dana Majed

Al-Radaideh, Ali
Awidi, Abdalla
Date
2020-08-21Submitted Date
2020-07-02Permanent link to this record
http://hdl.handle.net/10754/664959
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INTRODUCTION:People with multiple sclerosis (PwMS) experience a wide range of disabilities which negatively impact their quality of life (QOL). Several interventions have been used in PwMS such as medication, physical therapy exercises and stem cell therapy to improve their QOL. However, there is a limited evidence on the benefits of combining interventions. The purpose of this study is to explore the effect of combining physical therapy exercises (PTE) and Wharton Jelly mesenchymal stem cell (WJ-MSCs) injections on motor and non-motor symptoms versus each intervention alone in PwMS. METHODS:Sixty PwMS will be allocated to either PTE, WJ-MSCs, or a combined group, followed up for 12 months and examined using a comprehensive battery of measures. Participants in the PTE group will receive 2 sessions per week of a supervised exercise program for 6 months followed by a home exercise program for another 6 months. The WJ-MSCs group will receive 3 WJ-MSCs injections in the first 6 months then they will be encouraged to follow an active life style. The third group will receive both interventions. DISCUSSION:This study will aid in a better understanding of the combined effect of physical therapy and mesenchymal stem cell therapy. The results from this proposed study may reduce disability, improve QOL in PwMS, and consequently, reduce the cost associated with the life-time care of these individuals worldwide. TRIAL REGISTRATION NUMBER:NCT03326505.Citation
Alghwiri, A. A., Jamali, F., Aldughmi, M., Khalil, H., Al-Sharman, A., Alhattab, D., … Awidi, A. (2020). The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis. Medicine, 99(34), e21646. doi:10.1097/md.0000000000021646Sponsors
Authors would like to thank the CTC personnel, research assistants, and patients for their commitment to this trial.Journal
MedicinePubMed ID
32846775Additional Links
https://journals.lww.com/10.1097/MD.0000000000021646ae974a485f413a2113503eed53cd6c53
10.1097/md.0000000000021646
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Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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