The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis: A comparative study.
AuthorsAlghwiri, Alia A
Alhattab, Dana Majed
Permanent link to this recordhttp://hdl.handle.net/10754/664959
MetadataShow full item record
AbstractINTRODUCTION:People with multiple sclerosis (PwMS) experience a wide range of disabilities which negatively impact their quality of life (QOL). Several interventions have been used in PwMS such as medication, physical therapy exercises and stem cell therapy to improve their QOL. However, there is a limited evidence on the benefits of combining interventions. The purpose of this study is to explore the effect of combining physical therapy exercises (PTE) and Wharton Jelly mesenchymal stem cell (WJ-MSCs) injections on motor and non-motor symptoms versus each intervention alone in PwMS. METHODS:Sixty PwMS will be allocated to either PTE, WJ-MSCs, or a combined group, followed up for 12 months and examined using a comprehensive battery of measures. Participants in the PTE group will receive 2 sessions per week of a supervised exercise program for 6 months followed by a home exercise program for another 6 months. The WJ-MSCs group will receive 3 WJ-MSCs injections in the first 6 months then they will be encouraged to follow an active life style. The third group will receive both interventions. DISCUSSION:This study will aid in a better understanding of the combined effect of physical therapy and mesenchymal stem cell therapy. The results from this proposed study may reduce disability, improve QOL in PwMS, and consequently, reduce the cost associated with the life-time care of these individuals worldwide. TRIAL REGISTRATION NUMBER:NCT03326505.
CitationAlghwiri, A. A., Jamali, F., Aldughmi, M., Khalil, H., Al-Sharman, A., Alhattab, D., … Awidi, A. (2020). The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis. Medicine, 99(34), e21646. doi:10.1097/md.0000000000021646
SponsorsAuthors would like to thank the CTC personnel, research assistants, and patients for their commitment to this trial.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- The effect of a telerehabilitation virtual reality intervention on functional upper limb activities in people with multiple sclerosis: a study protocol for the TEAMS pilot randomized controlled trial.
- Authors: Kalron A, Achiron A, Pau M, Cocco E
- Issue date: 2020 Aug 12
- Pragmatic exercise intervention in people with mild to moderate multiple sclerosis: a randomised controlled feasibility study.
- Authors: Carter AM, Daley AJ, Kesterton SW, Woodroofe NM, Saxton JM, Sharrack B
- Issue date: 2013 Jul
- Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study.
- Authors: Albu S, Kumru H, Coll R, Vives J, Vallés M, Benito-Penalva J, Rodríguez L, Codinach M, Hernández J, Navarro X, Vidal J
- Issue date: 2021 Feb
- Effect of Multiple Sclerosis Cerebrospinal Fluid and Oligodendroglia Cell Line Environment on Human Wharton's Jelly Mesenchymal Stem Cells Secretome.
- Authors: Salwierak-Głośna K, Piątek P, Domowicz M, Świderek-Matysiak M
- Issue date: 2022 Feb 16
- High-intensity interval training and energy management education, compared with moderate continuous training and progressive muscle relaxation, for improving health-related quality of life in persons with multiple sclerosis: study protocol of a randomized controlled superiority trial with six months' follow-up.
- Authors: Patt N, Kool J, Hersche R, Oberste M, Walzik D, Joisten N, Caminada D, Ferrara F, Gonzenbach R, Nigg CR, Kamm CP, Zimmer P, Bansi J
- Issue date: 2021 Feb 11