• Login
    View Item 
    •   Home
    • Research
    • Articles
    • View Item
    •   Home
    • Research
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguideTheses and Dissertations LibguideSubmit an Item

    Statistics

    Display statistics

    Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    EEEfficient mimics.pdf
    Size:
    607.6Kb
    Format:
    PDF
    Description:
    Accepted article
    Download
    Type
    Article
    Authors
    Wang, Jian You cc
    Jamil, Muhammad cc
    Lin, Pei-Yu
    Ota, Tsuyoshi
    Fiorilli, Valentina
    Novero, Mara
    Zarban, Randa Alhassan Yahya cc
    Kountche, Boubacar Amadou cc
    Takahashi, Ikuo
    Martínez, Claudio
    Lanfranco, Luisa
    Bonfante, Paola
    de Lera, Angel R.
    Asami, Tadao
    Al-Babili, Salim cc
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Bioscience Program
    Center for Desert Agriculture
    Environmental Science and Engineering Program
    King Abdullah University of Science and Technology, Division of Biological and Environmental Science and Engineering, the BioActives Lab, Thuwal, 23955-6900, Saudi Arabia.
    Plant Science
    KAUST Grant Number
    CRG2017
    Date
    2020-08-21
    Online Publication Date
    2020-08-21
    Print Publication Date
    2020-11
    Embargo End Date
    2021-08-21
    Submitted Date
    2020-03-08
    Permanent link to this record
    http://hdl.handle.net/10754/664773
    
    Metadata
    Show full item record
    Abstract
    Zaxinone is an apocarotenoid regulatory metabolite required for normal rice growth and development. In addition, zaxinone has a large application potential in agriculture, due to its growth promoting activity and capability to alleviate infestation by the root parasitic plant Striga through decreasing strigolactone (SL) production. However, zaxinone is poorly accessible to the scientific community because of its laborious organic synthesis that impedes its further investigation and utilization. Here, we developed easy-to-synthesize and highly efficient mimics of zaxinone (MiZax). We performed a structure-activity-relationship study using a series of apocarotenoids distinguished from zaxinone by different structural features. Using the obtained results, we designed several phenyl-based compounds synthesized with a high-yield through a simple method. Activity tests showed that MiZax3 and MiZax5 exert zaxinone activity in rescuing root growth of a zaxinone-deficient rice mutant, promoting growth, and reducing SL content in roots and root exudates of wild-type plants. Moreover, these compounds were at least as efficient as zaxinone in suppressing transcript level of SL biosynthesis genes and in alleviating Striga infestation under greenhouse conditions, and did not negatively impact mycorrhization. Taken together, MiZax are a promising tool for elucidating zaxinone biology and investigating rice development, and suitable candidates for combating Striga and increasing crop growth.
    Citation
    Wang, J. Y., Jamil, M., Lin, P.-Y., Ota, T., Fiorilli, V., Novero, M., … Al-Babili, S. (2020). Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications. Molecular Plant. doi:10.1016/j.molp.2020.08.009
    Sponsors
    This work was supported by the Bill & Melinda Gates Foundation (Grant number: OPP1194472) and a Competitive Research Grant (CRG2017) given to S. A-B from King Abdullah University of Science and Technology (KAUST), and by grants from the Core Research for Evolutional Science and Technology (CREST) Program and the SATREPS Program of the Japan Science and Technology Agency (JST), and JSPS Grant-in-Aid for Scientific Research (grant number 18H03939) given to T. A.
    Publisher
    Elsevier BV
    Journal
    Molecular Plant
    DOI
    10.1016/j.molp.2020.08.009
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S1674205220302653
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.molp.2020.08.009
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Environmental Science and Engineering Program; Center for Desert Agriculture

    entitlement

     
    DSpace software copyright © 2002-2023  DuraSpace
    Quick Guide | Contact Us | KAUST University Library
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.