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    Benchmarking the Performance of Electropolymerized Poly(3,4-ethylenedioxythiophene) Electrodes for Neural Interfacing

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    Name:
    Nikiforidis_manuscript_revised_no highlight (1).pdf
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    853.5Kb
    Format:
    PDF
    Description:
    Accepted manuscript
    Embargo End Date:
    2021-08-21
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    Type
    Article
    Authors
    Nikiforidis, Georgios cc
    Wustoni, Shofarul cc
    Routier, Cyril
    Hama, Adel cc
    Koklu, Anil cc
    Saleh, Abdulelah cc
    Steiner, Nadia cc
    Druet, Victor cc
    Fiumelli, Hubert cc
    Inal, Sahika cc
    KAUST Department
    Bioengineering
    Bioengineering Program
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Organic Bioelectronics LaboratoryBiological Science and Engineering Division (BESE)King Abdullah University of Science and Engineering (KAUST) Thuwal 23955-6900 Saudi Arabia
    KAUST Grant Number
    OSR-2015-Sensors-2719
    Date
    2020-08-20
    Online Publication Date
    2020-08-20
    Print Publication Date
    2020-11
    Embargo End Date
    2021-08-21
    Submitted Date
    2020-06-22
    Permanent link to this record
    http://hdl.handle.net/10754/664767
    
    Metadata
    Show full item record
    Abstract
    The development of electronics adept at interfacing with the nervous system is an ever-growing effort, leading to discoveries in fundamental neuroscience applied in clinical setting. Highly capacitive and electrochemically stable electronic materials are paramount for these advances. A systematic study is presented where copolymers based on 3,4-ethylenedioxythiophene (EDOT) and its hydroxyl-terminated counterpart (EDOTOH) are electropolymerized in an aqueous solution in the presence of various counter anions and additives. Amongst the conducting materials developed, the copolymer p(EDOT-ran-EDOTOH) doped with perchlorate in the presence of ethylene glycol shows high specific capacitance (105 F g-1 ), and capacitance retention (85%) over 1000 galvanostatic charge-discharge cycles. A microelectrode array-based on this material is fabricated and primary cortical neurons are cultured therein for several days. The microelectrodes electrically stimulate targeted neuronal networks and record their activity with high signal-to-noise ratio. The stability of charge injection capacity of the material is validated via long-term pulsing experiments. While providing insights on the effect of additives and dopants on the electrochemical performance and operational stability of electropolymerized conducting polymers, this study highlights the importance of high capacitance accompanied with stability to achieve high performance electrodes for biological interfacing.
    Citation
    Nikiforidis, G., Wustoni, S., Routier, C., Hama, A., Koklu, A., Saleh, A., … Inal, S. (2020). Benchmarking the Performance of Electropolymerized Poly(3,4-ethylenedioxythiophene) Electrodes for Neural Interfacing. Macromolecular Bioscience, 2000215. doi:10.1002/mabi.202000215
    Sponsors
    The authors thank Prof. Pierre J. Magistretti and his team members at King Abdullah University of Science and Technology (KAUST) for supporting the preparation of neuronal cell culture. C.R. acknowledges the KAUST VRSP scholarship. This work was supported by KAUST Office of Sponsored Research (OSR) under Award No. OSR-2015-Sensors-2719.
    Publisher
    Wiley
    Journal
    Macromolecular Bioscience
    DOI
    10.1002/mabi.202000215
    PubMed ID
    32820588
    Additional Links
    https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.202000215
    ae974a485f413a2113503eed53cd6c53
    10.1002/mabi.202000215
    Scopus Count
    Collections
    Articles; Bioengineering Program; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program

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