Benchmarking the Performance of Electropolymerized Poly(3,4-ethylenedioxythiophene) Electrodes for Neural Interfacing
Biological and Environmental Sciences and Engineering (BESE) Division
Organic Bioelectronics LaboratoryBiological Science and Engineering Division (BESE)King Abdullah University of Science and Engineering (KAUST) Thuwal 23955-6900 Saudi Arabia
KAUST Grant NumberOSR-2015-Sensors-2719
Online Publication Date2020-08-20
Print Publication Date2020-11
Embargo End Date2021-08-21
Permanent link to this recordhttp://hdl.handle.net/10754/664767
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AbstractThe development of electronics adept at interfacing with the nervous system is an ever-growing effort, leading to discoveries in fundamental neuroscience applied in clinical setting. Highly capacitive and electrochemically stable electronic materials are paramount for these advances. A systematic study is presented where copolymers based on 3,4-ethylenedioxythiophene (EDOT) and its hydroxyl-terminated counterpart (EDOTOH) are electropolymerized in an aqueous solution in the presence of various counter anions and additives. Amongst the conducting materials developed, the copolymer p(EDOT-ran-EDOTOH) doped with perchlorate in the presence of ethylene glycol shows high specific capacitance (105 F g-1 ), and capacitance retention (85%) over 1000 galvanostatic charge-discharge cycles. A microelectrode array-based on this material is fabricated and primary cortical neurons are cultured therein for several days. The microelectrodes electrically stimulate targeted neuronal networks and record their activity with high signal-to-noise ratio. The stability of charge injection capacity of the material is validated via long-term pulsing experiments. While providing insights on the effect of additives and dopants on the electrochemical performance and operational stability of electropolymerized conducting polymers, this study highlights the importance of high capacitance accompanied with stability to achieve high performance electrodes for biological interfacing.
CitationNikiforidis, G., Wustoni, S., Routier, C., Hama, A., Koklu, A., Saleh, A., … Inal, S. (2020). Benchmarking the Performance of Electropolymerized Poly(3,4-ethylenedioxythiophene) Electrodes for Neural Interfacing. Macromolecular Bioscience, 2000215. doi:10.1002/mabi.202000215
SponsorsThe authors thank Prof. Pierre J. Magistretti and his team members at King Abdullah University of Science and Technology (KAUST) for supporting the preparation of neuronal cell culture. C.R. acknowledges the KAUST VRSP scholarship. This work was supported by KAUST Office of Sponsored Research (OSR) under Award No. OSR-2015-Sensors-2719.