Benchmarking the Performance of Electropolymerized Poly(3,4-ethylenedioxythiophene) Electrodes for Neural Interfacing
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ArticleAuthors
Nikiforidis, Georgios
Wustoni, Shofarul

Routier, Cyril
Hama, Adel

Koklu, Anil

Saleh, Abdulelah

Steiner, Nadia

Druet, Victor

Fiumelli, Hubert

Inal, Sahika

KAUST Department
BioengineeringBioengineering Program
Biological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Organic Bioelectronics LaboratoryBiological Science and Engineering Division (BESE)King Abdullah University of Science and Engineering (KAUST) Thuwal 23955-6900 Saudi Arabia
KAUST Grant Number
OSR-2015-Sensors-2719Date
2020-08-20Online Publication Date
2020-08-20Print Publication Date
2020-11Embargo End Date
2021-08-21Submitted Date
2020-06-22Permanent link to this record
http://hdl.handle.net/10754/664767
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Show full item recordAbstract
The development of electronics adept at interfacing with the nervous system is an ever-growing effort, leading to discoveries in fundamental neuroscience applied in clinical setting. Highly capacitive and electrochemically stable electronic materials are paramount for these advances. A systematic study is presented where copolymers based on 3,4-ethylenedioxythiophene (EDOT) and its hydroxyl-terminated counterpart (EDOTOH) are electropolymerized in an aqueous solution in the presence of various counter anions and additives. Amongst the conducting materials developed, the copolymer p(EDOT-ran-EDOTOH) doped with perchlorate in the presence of ethylene glycol shows high specific capacitance (105 F g-1 ), and capacitance retention (85%) over 1000 galvanostatic charge-discharge cycles. A microelectrode array-based on this material is fabricated and primary cortical neurons are cultured therein for several days. The microelectrodes electrically stimulate targeted neuronal networks and record their activity with high signal-to-noise ratio. The stability of charge injection capacity of the material is validated via long-term pulsing experiments. While providing insights on the effect of additives and dopants on the electrochemical performance and operational stability of electropolymerized conducting polymers, this study highlights the importance of high capacitance accompanied with stability to achieve high performance electrodes for biological interfacing.Citation
Nikiforidis, G., Wustoni, S., Routier, C., Hama, A., Koklu, A., Saleh, A., … Inal, S. (2020). Benchmarking the Performance of Electropolymerized Poly(3,4-ethylenedioxythiophene) Electrodes for Neural Interfacing. Macromolecular Bioscience, 2000215. doi:10.1002/mabi.202000215Sponsors
The authors thank Prof. Pierre J. Magistretti and his team members at King Abdullah University of Science and Technology (KAUST) for supporting the preparation of neuronal cell culture. C.R. acknowledges the KAUST VRSP scholarship. This work was supported by KAUST Office of Sponsored Research (OSR) under Award No. OSR-2015-Sensors-2719.Publisher
WileyJournal
Macromolecular BiosciencePubMed ID
32820588Additional Links
https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.202000215ae974a485f413a2113503eed53cd6c53
10.1002/mabi.202000215
Scopus Count
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