Examining histone modification crosstalk using immobilized libraries established from ligation-ready nucleosomes

Abstract
280 different patterns of histone modifications were installed in preassembled nucleosomes using PTS and SML enabling screening of readout crosstalk.

Citation
Aparicio Pelaz, D., Yerkesh, Z., Kirchgäßner, S., Mahler, H., Kharchenko, V., Azhibek, D., … Fischle, W. (2020). Examining histone modification crosstalk using immobilized libraries established from ligation-ready nucleosomes. Chemical Science. doi:10.1039/d0sc03407j

Acknowledgements
This work was supported by the priority program SPP 1623 of the Deutsche Forschungsgemeinscha (DFG FI1513/3-1 to W. F. and SCHW1163/4-1 to D. S.) the Max Planck Society (W. F.), and intramural funds of King Abdullah University of Science and Technology (M. J., L. J. and W. F.). We thank members of the HDM group for help with establishing protein trans-splicing assays.

Publisher
Royal Society of Chemistry (RSC)

Journal
Chemical Science

DOI
10.1039/d0sc03407j

Additional Links
http://xlink.rsc.org/?DOI=D0SC03407J

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