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    Laser scribed graphene: A novel platform for highly sensitive detection of eletroactive biomolecules

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    Description:
    Accepted Article
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    Type
    Article
    Authors
    Ghanam, Abdelghani cc
    Ait Lahcen, Abdellatif cc
    Beduk, Tutku cc
    Alshareef, Husam N. cc
    Amine, Aziz cc
    Salama, Khaled N. cc
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Functional Nanomaterials and Devices Research Group
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Sensors Lab
    Sensors Lab, Advanced Membranes and Porous Materials Center, Computer Electrical and Mathematical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia
    Date
    2020-08-19
    Online Publication Date
    2020-08-19
    Print Publication Date
    2020-11
    Embargo End Date
    2022-08-19
    Submitted Date
    2020-06-06
    Permanent link to this record
    http://hdl.handle.net/10754/664689
    
    Metadata
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    Abstract
    Laser-scribed graphene electrodes (LSGEs) have recently shown a potential for the development of electrochemical biosensors thanks to their electronic properties, porous structures, and large surface area that can support the charge transfer. In this paper, the authors present a comparative study of the electrochemical performances of LSGEs with the conventional screen-printed carbon electrodes (SPCEs) toward the detection of most commonly used phenolic compounds and biomolecules. Cyclic voltammetry measurements showed a significant enhancement in the electron transfer rate of all tested electroactive species at LSGEs compared to conventional SPCE. We have suggested, for the first time, a mechanistic study for catecholamine redox reactions at LSGE as the electron transfer–chemical reaction–electron transfer mechanism. Moreover, the excellent performances of LSGE were observed in terms of the electrocatalytic detection of paracetamol (PCM). Therefore, the second part of this study compared the analytical performances of LSGE and SPCE with respect to the detection of PCM. The LSGE allows a fast and reversible system for PCM with a low ΔEp of 88 mV while the SPCE exhibits a quasi-reversible system with a higher ΔEp of 384 mV. The LSGE demonstrated a PCM linear range of concentration between 0.1 μM and 10 μM, with a detection limit of 31 nM. In addition, the LSGE showed a successful applicability with good selectivity and sensitivity for PCM determination in real samples of pharmaceutical tablets. Hence, LSGEs could be an excellent platform for simple and low-cost electrochemical biosensor applications.
    Citation
    Ghanam, A., Lahcen, A. A., Beduk, T., Alshareef, H. N., Amine, A., & Salama, K. N. (2020). Laser scribed graphene: A novel platform for highly sensitive detection of eletroactive biomolecules. Biosensors and Bioelectronics, 112509. doi:10.1016/j.bios.2020.112509
    Sponsors
    The authors would like to express their acknowledgements to the financial support of funding from King Abdullah University of Science and Technology (KAUST), Saudi Arabia. Also, we thank the KAUST Sensor Initiative and KAUST Visiting Student Program for supporting this work. In addition, we would like to thank Dr Sakandar Rauf, Dr Veerappan Mani, Dr Sandeep G. Surya and Saravanan Yuvaraja for their suggestions and comments.
    Publisher
    Elsevier BV
    Journal
    Biosensors and Bioelectronics
    DOI
    10.1016/j.bios.2020.112509
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S0956566320305017
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bios.2020.112509
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Electrical and Computer Engineering Program; Material Science and Engineering Program; Sensors Lab; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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