Bortezomib-Encapsulated CuS/Carbon Dots Nanocomposites for Enhanced Photothermal Therapy via Stabilization of Polyubiquitinated Substrates in the Proteasomal Degradation Pathway
Type
ArticleAuthors
Yu, YingSong, Meiyu
Chen, Cailing

Du, Yangyang
Li, Chunguang
Han, Yu

Yan, Fei
Shi, Zhan
Feng, Shouhua
KAUST Department
Advanced Membranes and Porous Materials Research CenterChemical Science Program
Nanostructured Functional Materials (NFM) laboratory
Physical Science and Engineering (PSE) Division
Date
2020-08-11Online Publication Date
2020-08-11Print Publication Date
2020-08-25Embargo End Date
2021-08-11Permanent link to this record
http://hdl.handle.net/10754/664618
Metadata
Show full item recordAbstract
Photothermal therapy (PTT) is an emerging therapeutic strategy in the treatment of cancer; however, a critical challenge remains in the rational design of synergistic nanoparticles as potential photothermal transduction agent that can effectively enhance the therapeutic outcome of PTT for tumor ablation. Herein, we rationally designed, developed, and characterized hollow-structured CuS nanoparticles composited with carbon dots (CuSCD), which demonstrated excellent photothermal conversion efficiency under 808 nm laser irradiation with enhanced biocompatibility and reduced toxicity. Following coating macrophage membrane hybridized with T7 peptide on the surface of proteasome inhibitor loaded CuSCD, CuSCDB@MMT7 exhibited targeted specificity to cancer cells with the characteristics of immune escaping and enhanced transferrin receptor-mediated endocytosis. Predominantly, CuSCDB@MMT7-triggered PTT exhibited the accumulation of polyubiquitinated tumor suppressor protein that is heat stabilized under NIR induced hyperthermia, facilitating augmented tumor cell apoptosis and the attenuated metastasis. This study provides a proof-of-concept for the proteasome inhibitor-loaded CuS/carbon dots nanocomposites-PTT strategy, and highlights a promising therapeutic strategy for realizing enhanced therapeutic outcomes for effective clinical cancer therapy.Citation
Yu, Y., Song, M., Chen, C., Du, Y., Li, C., Han, Y., … Feng, S. (2020). Bortezomib-Encapsulated CuS/Carbon Dots Nanocomposites for Enhanced Photothermal Therapy via Stabilization of Polyubiquitinated Substrates in the Proteasomal Degradation Pathway. ACS Nano. doi:10.1021/acsnano.0c05332Sponsors
This work was supported by the National Natural Science Foundation of China (NSFC; nos. 81870117, 21771077, 21771084 and 21621001), the National Key Research and Development Program of China (no. 2016YFB0701100), the 111 project (no. B17020), and the Jilin Province Science and Technology Development Plan (20190201252JC). The authors also gratefully acknowledge the financial support by Program for JLU Science and Technology Innovative Research Team (JLUSTIRT).Publisher
American Chemical Society (ACS)Journal
ACS NanoAdditional Links
https://pubs.acs.org/doi/10.1021/acsnano.0c05332ae974a485f413a2113503eed53cd6c53
10.1021/acsnano.0c05332