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    3D High Spatial Resolution Visualisation and Quantification of Interconnectivity in Polymer Films.

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    Name:
    3D High Spatial Resolution Visualisation and Quantification of Interconnectivity in Polymer Films.pdf
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    46.56Mb
    Format:
    PDF
    Description:
    Accepted manuscript
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    Type
    Article
    Authors
    Fager, C cc
    Barman, S
    Röding, M
    Olsson, A
    Lorén, N
    von Corswant, C
    Bolin, David cc
    Rootzén, H
    Olsson, E
    KAUST Department
    Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division
    Date
    2020-07-12
    Online Publication Date
    2020-07-12
    Print Publication Date
    2020-09
    Embargo End Date
    2021-07-15
    Submitted Date
    2020-03-11
    Permanent link to this record
    http://hdl.handle.net/10754/664282
    
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    Abstract
    A porous network acts as transport paths for drugs through films for controlled drug release. The interconnectivity of the network strongly influences the transport properties. It is therefore important to quantify the interconnectivity and correlate it to transport properties for control and design of new films. This work presents a novel method for 3D visualisation and analysis of interconnectivity. High spatial resolution 3D data on porous polymer films for controlled drug release has been acquired using a focused ion beam (FIB) combined with a scanning electron microscope (SEM). The data analysis method enables visualisation of pore paths starting at a chosen inlet pore, dividing them into groups by length, enabling a more detailed quantification and visualisation. The method also enables identification of the central features of the porous network by quantification of channels where pore paths coincide. The method was applied to FIB-SEM data of three leached ethyl cellulose (EC)/hydroxypropyl cellulose (HPC) films with different weight percentages. The results from the analysis were consistent with the experimentally measured release properties of the films. The interconnectivity and porosity increase with increasing amount of HPC. The bottleneck effect was strong in the leached film with lowest porosity.
    Citation
    Fager, C., Barman, S., Röding, M., Olsson, A., Lorén, N., von Corswant, C., … Olsson, E. (2020). 3D High Spatial Resolution Visualisation and Quantification of Interconnectivity in Polymer Films. International Journal of Pharmaceutics, 119622. doi:10.1016/j.ijpharm.2020.119622
    Sponsors
    This work was funded by the Swedish Foundation for Strategic Research (SSF). The authors are grateful for the financial support. We wish to thank AstraZeneca for providing the material and Chalmers Material Analysis Laboratory for their support of microscopes. We also thank Prof. Aila Särkkä and everyone involved in the SSF project for valuable feedback; and for the feedback given at workshops organized by the Chalmers center SuMo Biomaterials and within the project COSIMA, both funded by Vinnova.
    Publisher
    Elsevier BV
    Journal
    International journal of pharmaceutics
    DOI
    10.1016/j.ijpharm.2020.119622
    PubMed ID
    32663584
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S0378517320306062
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijpharm.2020.119622
    Scopus Count
    Collections
    Articles; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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