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dc.contributor.authorAlsharif, Nouf
dc.contributor.authorAleisa, Fajr A
dc.contributor.authorLiu, Guangyu
dc.contributor.authorOoi, Boon S.
dc.contributor.authorPatel, Niketan Sarabhai
dc.contributor.authorRavasi, Timothy
dc.contributor.authorMerzaban, Jasmeen
dc.contributor.authorKosel, Jürgen
dc.date.accessioned2020-07-15T07:28:09Z
dc.date.available2020-07-15T07:28:09Z
dc.date.issued2020-07-08
dc.identifier.citationAlsharif, N. A., Aleisa, F. A., Liu, G., Ooi, B. S., Patel, N., Ravasi, T., … Kosel, J. (2020). Functionalization of Magnetic Nanowires for Active Targeting and Enhanced Cell Killing Efficacy. ACS Applied Bio Materials. doi:10.1021/acsabm.0c00312
dc.identifier.issn2576-6422
dc.identifier.issn2576-6422
dc.identifier.doi10.1021/acsabm.0c00312
dc.identifier.urihttp://hdl.handle.net/10754/664207
dc.description.abstractConventional chemotherapy and radiation therapy are often insufficient in eliminating cancer and are accompanied by severe side effects, due to a lack in the specificity of their targeting. Magnetic iron nanowires have made a great contribution to the nanomedicine field because of their low toxicity and ease of manipulation with the magnetic field. Recently, they have been used in magnetic resonance imaging, wireless magneto-mechanical, and photothermal treatments. The addition of active targeting moieties to these nanowires thus creates a multifunctional tool that can boost therapeutic efficacies through the combination of different treatments towards a specific target. Colon cancer is the third most commonly occurring cancer, and 90±2.5% of colon cancer cells express the glycoprotein CD44. Iron nanowires with an iron oxide surface are biocompatible, multifunctional materials that can be controlled by magnetic fields and heated by laser irradiation. Here, they were functionalized with anti-CD44 antibodies and used for in a combination therapy that included magneto-mechanical and photothermal treatments on colon cancer cells. The functionalization resulted in a threefold increase of nanowire internalization in colon cancer cells compared to control cells and did not affect the antigenicity and magnetic properties. It also increased the efficacy of killing from 35±1% to more than 71±2%, whereby the combination therapy was more effective than individual therapies alone.
dc.description.sponsorshipResearch reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST). This work has been partially funded by King Abdul-Aziz City for Science and Technology (KACST) General Directorate of Research Grants, Basic Research Grants Program [grant 151-34-TA].tudies. We also thank Samah Zeineb Gadhoum for her support and guidance regarding CD44.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/acsabm.0c00312
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsabm.0c00312.
dc.titleFunctionalization of Magnetic Nanowires for Active Targeting and Enhanced Cell Killing Efficacy
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentIntegrative Systems Biology Lab
dc.contributor.departmentPhotonics Laboratory
dc.contributor.departmentSensing, Magnetism and Microsystems Lab
dc.identifier.journalACS Applied Bio Materials
dc.eprint.versionPost-print
kaust.personAlsharif, Nouf Adnan
kaust.personAleisa, Fajr A
kaust.personLiu, Guangyu
kaust.personOoi, Boon S.
kaust.personPatel, Niketan Sarabhai
kaust.personRavasi, Timothy
kaust.personMerzaban, Jasmeen S.
kaust.personKosel, Jürgen
refterms.dateFOA2020-07-15T07:28:47Z
dc.date.published-online2020-07-08
dc.date.published-print2020-08-17


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