Functionalization of Magnetic Nanowires for Active Targeting and Enhanced Cell Killing Efficacy
Aleisa, Fajr A
Ooi, Boon S.
Patel, Niketan Sarabhai
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Integrative Systems Biology Lab
Sensing, Magnetism and Microsystems Lab
Online Publication Date2020-07-08
Print Publication Date2020-08-17
Permanent link to this recordhttp://hdl.handle.net/10754/664207
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AbstractConventional chemotherapy and radiation therapy are often insufficient in eliminating cancer and are accompanied by severe side effects, due to a lack in the specificity of their targeting. Magnetic iron nanowires have made a great contribution to the nanomedicine field because of their low toxicity and ease of manipulation with the magnetic field. Recently, they have been used in magnetic resonance imaging, wireless magneto-mechanical, and photothermal treatments. The addition of active targeting moieties to these nanowires thus creates a multifunctional tool that can boost therapeutic efficacies through the combination of different treatments towards a specific target. Colon cancer is the third most commonly occurring cancer, and 90±2.5% of colon cancer cells express the glycoprotein CD44. Iron nanowires with an iron oxide surface are biocompatible, multifunctional materials that can be controlled by magnetic fields and heated by laser irradiation. Here, they were functionalized with anti-CD44 antibodies and used for in a combination therapy that included magneto-mechanical and photothermal treatments on colon cancer cells. The functionalization resulted in a threefold increase of nanowire internalization in colon cancer cells compared to control cells and did not affect the antigenicity and magnetic properties. It also increased the efficacy of killing from 35±1% to more than 71±2%, whereby the combination therapy was more effective than individual therapies alone.
CitationAlsharif, N. A., Aleisa, F. A., Liu, G., Ooi, B. S., Patel, N., Ravasi, T., … Kosel, J. (2020). Functionalization of Magnetic Nanowires for Active Targeting and Enhanced Cell Killing Efficacy. ACS Applied Bio Materials. doi:10.1021/acsabm.0c00312
SponsorsResearch reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST). This work has been partially funded by King Abdul-Aziz City for Science and Technology (KACST) General Directorate of Research Grants, Basic Research Grants Program [grant 151-34-TA].tudies. We also thank Samah Zeineb Gadhoum for her support and guidance regarding CD44.
PublisherAmerican Chemical Society (ACS)
JournalACS Applied Bio Materials