Intramolecularly stapled amphiphatic peptides via boron-sugar interaction
Emwas, Abdul-Hamid M.
KAUST DepartmentBioscience Program
Biological and Environmental Sciences and Engineering (BESE) Division
Embargo End Date2021-06-23
Permanent link to this recordhttp://hdl.handle.net/10754/663873
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AbstractAmadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated in various positions of peptide chain was investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).
CitationKijewska, M., Czerwinska, A., Al-Harthi, S., Wołczański, G., Waliczek, M., Emwas, A.-H., … Szewczuk, Z. (2020). Intramolecularly stapled amphiphatic peptides via boron-sugar interaction. Chemical Communications. doi:10.1039/d0cc02603d
SponsorsThis work was supported by Grant No.UMO2015/19/B/ST5/00659 from the National Science Centre, Poland. The authors would like to thank Andrzej Reszka (ShimPol, Poland) for providing the Shimadzu LCMS-IT-TOF. LJ, MJ, SMA, and A-HE would like to thank the King Abdullah University of Science and Technology (KAUST) for financial support.
PublisherRoyal Society of Chemistry (RSC)