Intramolecularly stapled amphiphatic peptides via boron-sugar interaction

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Type
Article
Authors
Kijewska, Monika
Czerwinska, Angelika
Al-Harthi, Samah cc
Wołczański, Grzegorz
Waliczek, Mateusz
Emwas, Abdul-Hamid M.
Jaremko, Mariusz cc
Jaremko, Lukasz cc
Stefanowicz, Piotr
Szewczuk, Zbigniew
KAUST Department
Bioscience Program
NMR
Biological and Environmental Sciences and Engineering (BESE) Division
Date
2020
Embargo End Date
2021-06-23
Submitted Date
2020-04-10
Permanent link to this record
http://hdl.handle.net/10754/663873

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Abstract
Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated in various positions of peptide chain was investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).
Citation
Kijewska, M., Czerwinska, A., Al-Harthi, S., Wołczański, G., Waliczek, M., Emwas, A.-H., … Szewczuk, Z. (2020). Intramolecularly stapled amphiphatic peptides via boron-sugar interaction. Chemical Communications. doi:10.1039/d0cc02603d
Sponsors
This work was supported by Grant No.UMO2015/19/B/ST5/00659 from the National Science Centre, Poland. The authors would like to thank Andrzej Reszka (ShimPol, Poland) for providing the Shimadzu LCMS-IT-TOF. LJ, MJ, SMA, and A-HE would like to thank the King Abdullah University of Science and Technology (KAUST) for financial support.
Publisher
Royal Society of Chemistry (RSC)
Journal
Chemical Communications
DOI
10.1039/d0cc02603d
Additional Links
http://pubs.rsc.org/en/Content/ArticleLanding/2020/CC/D0CC02603D
Collections
Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program