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dc.contributor.authorWaliczek, Mateusz
dc.contributor.authorWierzbicka, Magdalena
dc.contributor.authorArkuszewski, Maciej
dc.contributor.authorKijewska, Monika
dc.contributor.authorJaremko, Lukasz
dc.contributor.authorRajagopal, Priyadharshni
dc.contributor.authorSzczepski, Kacper
dc.contributor.authorSroczyńska, Amanda
dc.contributor.authorJaremko, Mariusz
dc.contributor.authorStefanowicz, Piotr
dc.date.accessioned2020-06-25T06:02:11Z
dc.date.available2020-06-25T06:02:11Z
dc.date.issued2020-06-24
dc.date.submitted2020-02-14
dc.identifier.citationWaliczek, M., Wierzbicka, M., Arkuszewski, M., Kijewska, M., Jaremko, Ł., Rajagopal, P., … Stefanowicz, P. (2020). Attempting to synthesize lasso peptides using high pressure. PLOS ONE, 15(6), e0234901. doi:10.1371/journal.pone.0234901
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0234901
dc.identifier.urihttp://hdl.handle.net/10754/663847
dc.description.abstractLasso peptides are unique in that the tail of the lasso peptide threads through its macrolactam ring. The unusual structure and biological activity of lasso peptides have generated increased interest from the scientific community in recent years. Because of this, many new types of lasso peptides have been discovered. These peptides can be synthesized by microorganisms efficiently, and yet, their chemical assembly is challenging. Herein, we investigated the possibility of high pressure inducing the cyclization of linear precursors of lasso peptides. Unlike other molecules like rotaxanes which mechanically interlock at high pressure, the threaded lasso peptides did not form, even at pressures the high pressure up to 14000 kbar.
dc.description.sponsorshipThis work was supported by Grant No.UMO-2015/19/B/ST5/00659 from the National Science Centre, Poland https://www.ncn.gov.pl/ The co-authors: Łukasz Jaremko, Mariusz Jaremko, Priyadharshni Rajagopal and Kacper Szczepski are grateful to King Abdullah University of Science and Technology (KAUST) for financial support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.publisherPublic Library of Science (PLoS)
dc.relation.urlhttps://dx.plos.org/10.1371/journal.pone.0234901
dc.relation.urlhttps://doi.org/10.1371/journal.pone.0234901
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAttempting to synthesize lasso peptides using high pressure
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentBioscience
dc.identifier.journalPLOS ONE
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionFaculty of Chemistry, University of Wrocław, Wroclaw, Poland.
dc.identifier.volume15
dc.identifier.issue6
dc.identifier.pagese0234901
kaust.personJaremko, Lukasz
kaust.personRajagopal, Priyadharshni
kaust.personSzczepski, Kacper
kaust.personJaremko, Mariusz
dc.date.accepted2020-05-20
refterms.dateFOA2020-06-25T06:03:12Z


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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.