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dc.contributor.authorVu, Trieu-Duc
dc.contributor.authorIwasaki, Yuki
dc.contributor.authorShigenobu, Shuji
dc.contributor.authorMaruko, Akiko
dc.contributor.authorOshima, Kenshiro
dc.contributor.authorIioka, Erica
dc.contributor.authorHuang, Chao-Li
dc.contributor.authorAbe, Takashi
dc.contributor.authorTamaki, Satoshi
dc.contributor.authorLin, Yi-Wen
dc.contributor.authorChen, Chih-Kuan
dc.contributor.authorLu, Mei-Yeh
dc.contributor.authorHojo, Masaru
dc.contributor.authorWang, Hao-Ven
dc.contributor.authorTzeng, Shun-Fen
dc.contributor.authorHuang, Hao-Jen
dc.contributor.authorKanai, Akio
dc.contributor.authorGojobori, Takashi
dc.contributor.authorChiang, Tzen-Yuh
dc.contributor.authorSun, H Sunny
dc.contributor.authorLi, Wen-Hsiung
dc.contributor.authorOkada, Norihiro
dc.date.accessioned2020-06-21T12:27:14Z
dc.date.available2020-06-21T12:27:14Z
dc.date.issued2020-06-17
dc.date.submitted2019-09-18
dc.identifier.citationVu, T.-D., Iwasaki, Y., Shigenobu, S., Maruko, A., Oshima, K., Iioka, E., … Okada, N. (2020). Behavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens. PLOS Genetics, 16(6), e1008831. doi:10.1371/journal.pgen.1008831
dc.identifier.issn1553-7390
dc.identifier.pmid32555673
dc.identifier.doi10.1371/journal.pgen.1008831
dc.identifier.urihttp://hdl.handle.net/10754/663732
dc.description.abstractConspecific male animals fight for resources such as food and mating opportunities but typically stop fighting after assessing their relative fighting abilities to avoid serious injuries. Physiologically, how the fighting behavior is controlled remains unknown. Using the fighting fish Betta splendens, we studied behavioral and brain-transcriptomic changes during the fight between the two opponents. At the behavioral level, surface-breathing, and biting/striking occurred only during intervals between mouth-locking. Eventually, the behaviors of the two opponents became synchronized, with each pair showing a unique behavioral pattern. At the physiological level, we examined the expression patterns of 23,306 brain transcripts using RNA-sequencing data from brains of fighting pairs after a 20-min (D20) and a 60-min (D60) fight. The two opponents in each D60 fighting pair showed a strong gene expression correlation, whereas those in D20 fighting pairs showed a weak correlation. Moreover, each fighting pair in the D60 group showed pair-specific gene expression patterns in a grade of membership analysis (GoM) and were grouped as a pair in the heatmap clustering. The observed pair-specific individualization in brain-transcriptomic synchronization (PIBS) suggested that this synchronization provides a physiological basis for the behavioral synchronization. An analysis using the synchronized genes in fighting pairs of the D60 group found genes enriched for ion transport, synaptic function, and learning and memory. Brain-transcriptomic synchronization could be a general phenomenon and may provide a new cornerstone with which to investigate coordinating and sustaining social interactions between two interacting partners of vertebrates.
dc.description.sponsorshipThis study was completed at the Foundation for Advancement of International Science (FAIS) and Kitasato University, Japan. We thank Mr. Y. Otake, a president of FAIS, and Mr. T. Sugino, a president of ZENICK Corp., for support. We thank Drs. P-W. Gean and K. Yamaguchi for discussions and the preliminary analysis of the data. We are also grateful to Drs. K. Honma, J. Wang and S. Nishimura for critical reading of the manuscript, to Ms. A. Koizumi for improving the quality of the figures, and to Mr. K. Onodera at FAIS for assistance. We thank Drs. Alison Bell (Guest Editor), Gregory Barsh (Editor-in-Chief), and the three anonymous reviewers for their constructive comments, which have improved the manuscript.
dc.publisherPublic Library of Science (PLoS)
dc.relation.urlhttps://dx.plos.org/10.1371/journal.pgen.1008831
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleBehavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.identifier.journalPLoS genetics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionSchool of Pharmacy, Kitasato University, Tokyo, Japan.
dc.contributor.institutionFoundation for Advancement of International Science, Tsukuba, Japan.
dc.contributor.institutionLife Sciences and Biotechnology Dept, Tokyo Institute of Technology, Tokyo, Japan.
dc.contributor.institutionBiodiversity Research Center, Academia Sinica, Taipei, Taiwan.
dc.contributor.institutionDepartment of Life Sciences, National Cheng Kung University, Tainan, Taiwan.
dc.contributor.institutionNagahama Institute of Bio-Science and Technology, Nagahama, Japan.
dc.contributor.institutionNational Institute for Basic Biology, Okazaki, Japan.
dc.contributor.institutionInstitute of Tropical Plant Sciences, National Cheng Kung University, Tainan, Taiwan.
dc.contributor.institutionGraduate School of Science and Technology, Niigata University, Niigata, Japan, 10 Institute for Advanced Biosciences, Keio University, Yamagata, Japan.
dc.contributor.institutionInstitute for Advanced Biosciences, Keio University, Yamagata, Japan.
dc.contributor.institutionInstitute of Molecular Medicine, National Cheng Kung University, Tainan, Taiwan.
dc.contributor.institutionDepartment of Ecology and Evolution, University of Chicago, IL, United States of America.
dc.identifier.volume16
dc.identifier.issue6
dc.identifier.pagese1008831
kaust.personGojobori, Takashi
dc.date.accepted2020-05-05
refterms.dateFOA2020-06-21T12:29:01Z


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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.