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    Proteomic responses to ocean acidification in the brain of juvenile coral reef fish

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    Type
    Preprint
    Authors
    Tsang, Hin Hung
    Welch, Megan
    Munday, Philip L.
    Ravasi, Timothy
    Schunter, Celia Marei cc
    KAUST Grant Number
    OCRF-2014-CRG3-62140408
    Date
    2020-05-28
    Permanent link to this record
    http://hdl.handle.net/10754/663645
    
    Metadata
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    Abstract
    AbstractElevated CO2 levels predicted to occur by the end of the century can affect the physiology and behaviour of marine fishes. For one important survival mechanism, the response to chemical alarm cues from conspecifics, substantial among-individual variation in the extent of behavioural impairment when exposed to elevated CO2 has been observed in previous studies. Whole brain transcriptomic data has further emphasized the importance of parental phenotypic variation in the response of juvenile fish to elevated CO2. In this study, we investigate the genome-wide proteomic responses of this variation in the brain of 5-week old spiny damselfish, Acanthochromis polyacanthus. We compared the expression of proteins in the brains of juvenile A. polyacanthus from two different parental behavioural phenotypes (sensitive and tolerant) that had been experimentally exposed to short-term, long-term and inter-generational elevated CO2. Our results show differential expression of key proteins related to stress response and epigenetic markers with elevated CO2 exposure. Proteins related to neurological development were also differentially expressed particularly in the long-term developmental treatment, which might be critical for juvenile development. By contrast, exposure to elevated CO2 in the parental generation resulted in only three differentially expressed proteins in the offspring, revealing potential for inter-generational acclimation. Lastly, we found a distinct proteomic pattern in juveniles due to the behavioural sensitivity of parents to elevated CO2, even though the behaviour of the juvenile fish was impaired regardless of parental phenotype. Our data shows that developing juveniles are affected in their brain protein expression by elevated CO2, but the effect varies with the length of exposure as well as due to variation of parental phenotypes in the population.
    Citation
    Tsang, H. H., Welch, M., Munday, P. L., Ravasi, T., & Schunter, C. (2020). Proteomic responses to ocean acidification in the brain of juvenile coral reef fish. doi:10.1101/2020.05.25.115527
    Sponsors
    This study was supported by the Australian Research Council (ARC) and the ARC Centre of Excellence for Coral Reef Studies (P.L.M), the Office of Competitive Research Funds OCRF-2014-CRG3-62140408 from the King Abdullah University of Science and Technology (T.R., P.L.M., C.S.). This project was completed under James Cook University (JCU) ethics permit A1828. We thank the Marine and Aquaculture Research Facilities Unit (JCU), the Schunter lab members at the Swire Institute of Marine Science (SWIMS) and Biosciences Core Laboratory (KAUST) for support and assistance.
    Publisher
    Cold Spring Harbor Laboratory
    DOI
    10.1101/2020.05.25.115527
    Additional Links
    http://biorxiv.org/lookup/doi/10.1101/2020.05.25.115527
    https://www.biorxiv.org/content/biorxiv/early/2020/05/28/2020.05.25.115527.full.pdf
    ae974a485f413a2113503eed53cd6c53
    10.1101/2020.05.25.115527
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