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    Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from Bursatella leachii Viscera

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    Type
    Article
    Authors
    Dhahri, Manel cc
    Sioud, Salim
    Dridi, Rihab
    Hassine, Mohsen
    Boughattas, Naceur A.
    Almulhim, Fatimah F. cc
    Al-Talla, Zeyad
    Jaremko, Mariusz cc
    Emwas, Abdul-Hamid M.
    KAUST Department
    Ali I. Al-Naimi Petroleum Engineering Research Center (ANPERC)
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience
    Bioscience Program
    NMR
    Organics
    Physical Science and Engineering (PSE) Division
    KAUST Grant Number
    BAS/1/1085-01-01
    Date
    2020-06-10
    Online Publication Date
    2020-06-10
    Print Publication Date
    2020-06-23
    Permanent link to this record
    http://hdl.handle.net/10754/663499
    
    Metadata
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    Abstract
    Bioactive compounds for drug discovery are increasingly extracted and purified from natural sources including marine organisms. Heparin is a therapeutic agent that has been used for several decades as an anticoagulant. However, heparin is known to cause many undesirable complications such as thrombocytopenia and risk of hemorrhage. Hence, there is a need to find alternatives to current widely used anticoagulant drugs. Here, we extract a sulfated polysaccharide from sea hare, that is, Bursatella leachii viscera, by enzymatic digestion. Several analytical approaches including elemental analysis, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, and high-performance liquid chromatography–mass spectrometry analysis show that B. leachii polysaccharides have chemical structures similar to glycosaminoglycans. We explore the anticoagulant activity of the B. leachii extract using the activated partial thromboplastin time and the thrombin time. Our results demonstrate that the extracted sulfated polysaccharide has heparin-like anticoagulant activity, thus showing great promise as an alternative anticoagulant therapy.
    Citation
    Dhahri, M., Sioud, S., Dridi, R., Hassine, M., Boughattas, N. A., Almulhim, F., … Emwas, A.-H. M. (2020). Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from Bursatella leachii Viscera. ACS Omega. doi:10.1021/acsomega.0c01724
    Sponsors
    This work was supported by Taibah university and King Abdullah University of Science and Technology (under fund number BAS/1/1085-01-01) to M.J.
    Publisher
    American Chemical Society (ACS)
    Journal
    ACS Omega
    DOI
    10.1021/acsomega.0c01724
    Additional Links
    https://pubs.acs.org/doi/10.1021/acsomega.0c01724
    ae974a485f413a2113503eed53cd6c53
    10.1021/acsomega.0c01724
    Scopus Count
    Collections
    Articles; Ali I. Al-Naimi Petroleum Engineering Research Center (ANPERC); Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Physical Science and Engineering (PSE) Division

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