Mesoporous Strontium-Doped Phosphate-Based Sol-Gel Glasses for Biomedical Applications.
Kyffin, Benjamin Alexander
Knowles, Jonathan C
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/662830
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AbstractMesoporous phosphate-based glasses have great potential as biomedical materials being able to simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In the present study, a series of mesoporous phosphate-based glasses in the P2O5-CaO-Na2O system, doped with 1, 3, and 5 mol% of Sr2+, were prepared using the sol-gel method combined with supramolecular templating. A sample without strontium addition was prepared for comparison. The non-ionic triblock copolymer EO20PO70EO20 (P123) was used as a templating agent. Scanning electron microscopy (SEM) images revealed that all synthesized glasses have an extended porous structure. This was confirmed by N2 adsorption-desorption analysis at 77 K that shows a porosity typical of mesoporous materials. 31P magic angle spinning nuclear magnetic resonance (31P MAS-NMR) and Fourier transform infrared (FTIR) spectroscopies have shown that the glasses are mainly formed by Q1 and Q2 phosphate groups. Degradation of the glasses in deionized water assessed over a 7-day period shows that phosphate, Ca2+, Na+, and Sr2+ ions can be released in a controlled manner over time. In particular, a direct correlation between strontium content and degradation rate was observed. This study shows that Sr-doped mesoporous phosphate-based glasses have great potential in bone tissue regeneration as materials for controlled delivery of therapeutic ions.
CitationForoutan, F., Kyffin, B. A., Abrahams, I., Knowles, J. C., Sogne, E., Falqui, A., & Carta, D. (2020). Mesoporous Strontium-Doped Phosphate-Based Sol-Gel Glasses for Biomedical Applications. Frontiers in Chemistry, 8. doi:10.3389/fchem.2020.00249
SponsorsThe authors are grateful to Dr. David Jones for his help with the SEM/EDX and Dr. Graham Palmer for his help with ICPOES measurements.
PublisherFrontiers Media SA
JournalFrontiers in chemistry
Except where otherwise noted, this item's license is described as Archived with thanks to Frontiers in chemistry
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