Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds
Type
ArticleAuthors
Merkes, Jean MichelZhu, Leiming
Bahukhandi, Srishti Ballabh
Rueping, Magnus

Kiessling, Fabian

Banala, Srinivas
KAUST Department
Chemical Science ProgramKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2020-04-27Submitted Date
2020-03-31Permanent link to this record
http://hdl.handle.net/10754/662682
Metadata
Show full item recordAbstract
Photoacoustic imaging (PAI) is a rapidly evolving field in molecular imaging that enables imaging in the depths of ultrasound and with the sensitivity of optical modalities. PAI bases on the photoexcitation of a chromophore, which converts the absorbed light into thermal energy, causing an acoustic pressure wave that can be captured with ultrasound transducers, in generating an image. For in vivo imaging, chromophores strongly absorbing in the near-infrared range (NIR; > 680 nm) are required. As tetrapyrroles have a long history in biomedical applications, novel tetrapyrroles and inspired mimics have been pursued as potentially suitable contrast agents for PAI. The goal of this review is to summarize the current state of the art in PAI applications using tetrapyrroles and related macrocycles inspired by it, highlighting those compounds exhibiting strong NIR-absorption. Furthermore, we discuss the current developments of other absorbers for in vivo photoacoustic (PA) applications.Citation
Merkes, J. M., Zhu, L., Bahukhandi, S. B., Rueping, M., Kiessling, F., & Banala, S. (2020). Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds. International Journal of Molecular Sciences, 21(9), 3082. doi:10.3390/ijms21093082Publisher
MDPI AGAdditional Links
https://www.mdpi.com/1422-0067/21/9/3082https://www.mdpi.com/1422-0067/21/9/3082/pdf
ae974a485f413a2113503eed53cd6c53
10.3390/ijms21093082