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dc.contributor.authorMohammed, Hiba
dc.contributor.authorKumar, Ajay
dc.contributor.authorBekyarova, Elena
dc.contributor.authorAl-Hadeethi, Yas M.
dc.contributor.authorZhang, Xixiang
dc.contributor.authorChen, Mingguang
dc.contributor.authorAnsari, Shahnawaze
dc.contributor.authorCochis, Andrea
dc.contributor.authorRimondini, Lia
dc.date.accessioned2020-04-27T14:36:53Z
dc.date.available2020-04-27T14:36:53Z
dc.date.issued2020-05-25
dc.date.submitted2019-09-17
dc.identifier.citationMohammed, H., Kumar, A., Bekyarova, E., Al-Hadeethi, Y., Zhang, X., Chen, M., … Rimondini, L. (2020). Antimicrobial Mechanisms and Effectiveness of Graphene and Graphene-Functionalized Biomaterials. A Scope Review. Frontiers in Bioengineering and Biotechnology, 8. doi:10.3389/fbioe.2020.00465
dc.identifier.doi10.3389/fbioe.2020.00465
dc.identifier.urihttp://hdl.handle.net/10754/662665
dc.description.abstractBacterial infections represent nowadays the major reason of biomaterials implant failure; however, most of the available implantable materials do not hold antimicrobial properties, thus requiring antibiotic therapy once the infection occurs. The fast raising of antibiotic-resistant pathogens is making this approach as not more effective, leading to the only solution of device removal and causing devastating consequences for patients. Accordingly, there is a large research about alternative strategies based on the employment of materials holding intrinsic antibacterial properties in order to prevent infections. Between these new strategies, new technologies involving the use of carbon-based materials such as carbon nanotubes, fullerene, graphene and diamond-like carbon shown very promising results. In particular, graphene- and graphene-derived materials (GMs) demonstrated a broad range antibacterial activity towards bacteria, fungi and viruses. These antibacterial activities are attributed mainly to the direct physicochemical interaction between GMs and bacteria that cause a deadly deterioration of cellular components, principally proteins, lipids, and nucleic acids. In fact, GMs hold a high affinity to the membrane proteoglycans where they accumulate leading to membrane damages; similarly, after internalization they can interact with bacteria RNA/DNA hydrogen groups interrupting the replicative stage. Moreover, GMs can indirectly determine bacterial death by activating the inflammatory cascade due to active species generation after entering in the physiological environment. On the opposite, despite these bacteria-targeted activities, GMs have been successfully employed as pro-regenerative materials to favor tissue healing for different tissue engineering purposes. Taken into account these GMs biological properties, this review aims at explaining the antibacterial mechanisms underlying graphene as a promising material applicable in biomedical devices.
dc.description.sponsorshipThis project received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 814558.
dc.language.isoen
dc.publisherFrontiers Media SA
dc.relation.urlhttps://www.frontiersin.org/articles/10.3389/fbioe.2020.00465/abstract
dc.rightsArchived with thanks to Frontiers in Bioengineering and Biotechnology. © 2020 Mohammed, Kumar, Bekyarova, Al-Hadeethi, Zhang, Chen, Ansari, Cochis and Rimondini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAntimicrobial mechanisms and effectiveness of graphene and graphene-functionalized biomaterials. A scope review.
dc.typeArticle
dc.contributor.departmentMaterial Science and Engineering Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalFrontiers in Bioengineering and Biotechnology
dc.eprint.versionPost-print
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
pubs.publication-statusAccepted
kaust.personZhang, Xixiang
kaust.personChen, Mingguang
refterms.dateFOA2020-04-27T14:36:54Z


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Archived with thanks to Frontiers in Bioengineering and Biotechnology. © 2020 Mohammed, Kumar, Bekyarova, Al-Hadeethi, Zhang, Chen, Ansari, Cochis and Rimondini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as Archived with thanks to Frontiers in Bioengineering and Biotechnology. © 2020 Mohammed, Kumar, Bekyarova, Al-Hadeethi, Zhang, Chen, Ansari, Cochis and Rimondini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.