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    Probing the Diversity of Polycomb and Trithorax Proteins in Cultured and Environmentally Sampled Microalgae

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    Probing the diversity.pdf
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    Type
    Article
    Authors
    Zhao, Xue
    Deton Cabanillas, Anne Flore
    Veluchamy, Alaguraj
    Bowler, Chris
    Vieira, Fabio Rocha Jimenez
    Tirichine, Leila
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2020-03-31
    Submitted Date
    2019-12-09
    Permanent link to this record
    http://hdl.handle.net/10754/662438
    
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    Abstract
    Polycomb (PcG) and Trithorax (TrxG) complexes are two evolutionarily conserved epigenetic regulatory components that act antagonistically to regulate the expression of genes involved in cell differentiation and development in multicellular organisms. The absence of PcG in both yeast models Saccharomyces cerevisiae and Schizosaccharomyces pombe suggested that polycomb proteins might have evolved together with the emergence of multicellular organisms. However, high throughput sequencing of several microalgal genomes and transcriptomes reveals an unprecedented abundance and diversity of genes encoding the components of these complexes. We report here the diversity of genes encoding PcG and TrxG proteins in microalgae from the Marine Microbial Eukaryote Transcriptome Sequencing Project database (MMETSP) and detected at broad scale in Tara Oceans genomics datasets using a highly sensitive method called eDAF (enhanced Domain Architecture Filtering). Further, we explored the correlation between environmental factors measured during the Tara Oceans expedition and transcript levels of PcG and TrxG components. PcG and TrxG are responsible for the deposition of a number of histone marks among which a TrxG associated mark, H3K4me3 which we profiled genome wide in the model diatom Phaeodactylum tricornutum to understand its role in microalgae and revisited the previously published histone code and co-occurrence with other histone marks including the antagonizing Polycomb deposited mark H3K27me3.
    Citation
    Zhao, X., Deton Cabanillas, A. F., Veluchamy, A., Bowler, C., Vieira, F. R. J., & Tirichine, L. (2020). Probing the Diversity of Polycomb and Trithorax Proteins in Cultured and Environmentally Sampled Microalgae. Frontiers in Marine Science, 7. doi:10.3389/fmars.2020.00189
    Sponsors
    LT acknowledges funds from the CNRS and the region of Pays de la Loire (ConnecTalent EPIALG project). CB acknowledges the European Research Council Advanced Award Diatomite. XZ was supported by a Ph.D. fellowship from the Chinese Scholarship Council (CSC-201604910722).
    Publisher
    Frontiers Media SA
    Journal
    Frontiers in Marine Science
    DOI
    10.3389/fmars.2020.00189
    Additional Links
    https://www.frontiersin.org/article/10.3389/fmars.2020.00189/full
    ae974a485f413a2113503eed53cd6c53
    10.3389/fmars.2020.00189
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division

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