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dc.contributor.authorBajic, Vladan P.
dc.contributor.authorEssack, Magbubah
dc.contributor.authorZivkovic, Lada
dc.contributor.authorStewart, Alan
dc.contributor.authorZafirovic, Sonja
dc.contributor.authorBajic, Vladimir B.
dc.contributor.authorGojobori, Takashi
dc.contributor.authorIsenovic, Esma
dc.contributor.authorSpremo-Potparevic, Biljana
dc.date.accessioned2020-02-24T12:20:39Z
dc.date.available2020-02-24T12:20:39Z
dc.date.issued2020-01-28
dc.date.submitted2019-09-25
dc.identifier.citationBajic, V. P., Essack, M., Zivkovic, L., Stewart, A., Zafirovic, S., Bajic, V. B., … Spremo-Potparevic, B. (2020). The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease.” Frontiers in Genetics, 10. doi:10.3389/fgene.2019.01368
dc.identifier.doi10.3389/fgene.2019.01368
dc.identifier.urihttp://hdl.handle.net/10754/661656
dc.description.abstractAlzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only the apolipoprotein E4 (ApoE4) gene has been proved to be a genetic risk factor for late-onset AD (LOAD). In recent years, despite the hypothesis that many additional unidentified genes are likely to play a role in AD development, it is surprising that additional gene polymorphisms associated with LOAD have failed to come to light. In this review, we examine the role of X chromosome epigenetics and, based upon GWAS studies, the PCDHX11 gene. Furthermore, we explore other genetic risk factors of AD that involve X-chromosome epigenetics.
dc.description.sponsorshipThis work is part of the collaboration between the Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Saudi Arabia. This work has been supported by grants No. 173033 (EI) and No. 173034 (VPB) from the Ministry of Education, Science and Technological Development, Republic of Serbia and by the KAUST grant OSR#4129 (to EI and VBB), which also supported SZ and VPB. VBB has been supported by the KAUST Base Research Fund (BAS/1/1606-01-01), while VBB and ME have been supported by KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01. TG has been supported by the King Abdullah University of Science and Technology (KAUST) Base Research Fund (BAS/1/1059-01-01).
dc.publisherFrontiers Media SA
dc.relation.urlhttps://www.frontiersin.org/article/10.3389/fgene.2019.01368/full
dc.relation.urlhttps://www.frontiersin.org/articles/10.3389/fgene.2019.01368/pdf
dc.rightsArchived with thanks to Frontiers in Genetics
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalFrontiers in Genetics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionLaboratory for Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia
dc.contributor.institutionDepartment of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
dc.contributor.institutionSchool of Medicine, University of St Andrews, St Andrews, United Kingdom
kaust.personEssack, Magbubah
kaust.personBajic, Vladimir B.
kaust.personGojobori, Takashi
kaust.personGojobori, Takashi
kaust.grant.numberBAS/1/1606-01-01
kaust.grant.numberFCC/1/1976-17-01
kaust.grant.numberOSR#4129
dc.date.accepted2019-12-13
refterms.dateFOA2020-02-24T12:22:42Z
kaust.acknowledged.supportUnitComputational Bioscience Research Center (CBRC)
kaust.acknowledged.supportUnitKAUST Office of Sponsored Research (OSR)


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