Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Single-Molecule Spectroscopy and Microscopy Research Group
Online Publication Date2019-12-18
Print Publication Date2020-02-14
Permanent link to this recordhttp://hdl.handle.net/10754/661426
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AbstractDevelopment of near-infrared (NIR) and shortwave infrared (SWIR) emitting fluorophores is central to the fluorescence-based bioimaging. While conjugated polymer nanoparticles (polymer dots) are one of the promising fluorophores for this application, obtaining polymer dots that show bright fluorescence, especially in the SWIR wavelength region, has been challenging. Here, we report a generalized approach to obtain bright polymer dots through a systematic characterization of photophysical properties of NIR and SWIR emitting polymer dots. Detailed photophysical characterization of a series of polymer dots fabricated using polycarbazole- (PCz-) based conjugated polymers that adopt bent and twisted conformation reveals that the fluorescence brightness of the PCz-based polymer dots is determined by subtle balance between fluorescence quenching due to polymer chain interaction inside the particles and the twisting between the donor and acceptor moieties of the conjugated polymers inside the particles. Our results provide important insight into the rational design of highly fluorescing SWIR-emitting polymer dots.
CitationPiwoński, H., Li, W., Wang, Y., Michinobu, T., & Habuchi, S. (2019). Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications. ACS Applied Polymer Materials. doi:10.1021/acsapm.9b00967
SponsorsThe research reported in this publication was supported by King Abdullah University of Science and Technology (KAUST) and the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-2967-CRG5. We thank Dr. Hiroyuki Fujita (Tokyo Institute of Technology) for assistance in the polymer synthesis.
PublisherAmerican Chemical Society (ACS)
JournalACS Applied Polymer Materials