Phenoxylation of Alkynes Through Mono- and Dual-Activation using Group 11 (Cu, Ag, Au) Catalysts
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Online Publication Date2020-02-04
Print Publication Date2020-03-27
Embargo End Date2021-01-07
Permanent link to this recordhttp://hdl.handle.net/10754/661402
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AbstractNHC-gold(I) based catalysts have displayed outstanding results toward hydroalkoxylation of terminal and internal alkynes in solvent-free conditions and using low catalyst loadings. It has been demonstrated that, in the hydrophenoxylation reaction the gold complex is composed by two moieties that determine the rate of the reaction by activating both substrates synergistically, i.e. [Au(OR)(NHC)] and [Au(η2-alkyne)(NHC)]+. Then, these bimetallic systems act cooperatively toward the hydroalkoxylation reaction. Herein, density functional theory studies were carried out to get insights on the mechanism of hydrophenoxylation. The rate-determining step, which corresponds to the formation of the C(alkyne)–O(alcohol) bond between [Au(OR)(NHC)] and [Au(η2-alkyne)(NHC)]+, was studied using energy decomposition analyses (EDA). It was found that the C–O bond shows strong electrostatic and orbital interactions between both fragments in the homobimetallic, heterobimetallic and monogold mechanisms. Moreover, the analyses were expanded to copper and argentum, and the steric sensibility was also studied through the use of different NHC ligands, including IMes, IMe, SIMes, IPr, and IPr*, that differ on their steric demand.
CitationRamos, M., Poater, J., Villegas-Escobar, N., Gimferrer, M., Toro-Labbé, A., Cavallo, L., & Poater, A. (2020). Phenoxylation of Alkynes Through Mono- and Dual-Activation using Group 11 (Cu, Ag, Au) Catalysts. European Journal of Inorganic Chemistry. doi:10.1002/ejic.201901220
SponsorsA. P. is a Serra Húnter Fellow and ICREA Academia 2019. A. P. and J. P. are grateful to the Ministerio de Economía y Competitividad (MINECO) of Spain (projects PGC2018–097722-B-I00 and CTQ2016–77558-R, MDM-2017–0767), the Generalitat de Catalunya (projects 2017SGR39 and 2017SGR348). M. G. thanks the Generalitat de Catalunya and Fons Social Europeu for the predoctoral fellowship (2018 FI_B 01120). We thank Prof. Dr. Miquel Solà for helpful comments.