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dc.contributor.authorAugustine, Dhanya
dc.contributor.authorHadjichristidis, Nikos
dc.contributor.authorGnanou, Yves
dc.contributor.authorFeng, Xiaoshuang
dc.date.accessioned2020-02-03T05:56:21Z
dc.date.available2020-02-03T05:56:21Z
dc.date.issued2020-01-30
dc.date.submitted2019-12-16
dc.identifier.citationAugustine, D., Hadjichristidis, N., Gnanou, Y., & Feng, X. (2020). Hydrophilic Stars, Amphiphilic Star Block Copolymers, and Miktoarm Stars with Degradable Polycarbonate Cores. Macromolecules. doi:10.1021/acs.macromol.9b02658
dc.identifier.doi10.1021/acs.macromol.9b02658
dc.identifier.urihttp://hdl.handle.net/10754/661351
dc.description.abstractA facile one-pot synthetic approach toward the realization of star polymers made of degradable carbonate cores is reported. The synthetic strategy involved triethylborane-activated anionic copolymerization of a difunctional epoxide with CO2 initiated by bis(triphenylphosphine)iminium chloride (PPNCl).Vinyl cyclohexene dioxide (VCD) was, thus, used as a difunctional cross-linker, and core compositions with 80−90% carbonate content were achieved. Poly(ethylene oxide) (PEO) arms were grown from these in-situ generated polycarbonate core anions to build a range of star polymers, including hydrophilic PEO stars and star-shaped block copolymers. Poly(propylene oxide) (PPO) precursors were used in a second approach as macroinitiators to form carbonate cores through the arm-first method; miktoarm stars having a large number of arms, both hydrophilic and hydrophobic, could be derived by this method. The carbonate cores of the synthesized stars were readily degraded through hydrolysis of the core carbonate linkages to yield PEO and PPO chains. Potential applications of these types of systems are manifold, especially for PEGbased drug delivery vehicles.
dc.description.sponsorshipThis research work was supported by KAUST under baseline funding (BAS/1/1374-01-01).
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/acs.macromol.9b02658
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Macromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.macromol.9b02658.
dc.titleHydrophilic Stars, Amphiphilic Star Block Copolymers, and Miktoarm Stars with Degradable Polycarbonate Cores
dc.typeArticle
dc.contributor.departmentAcademic Affairs
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentOffice of the VP
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentPolymer Synthesis Laboratory
dc.identifier.journalMacromolecules
dc.rights.embargodate2021-01-30
dc.eprint.versionPost-print
kaust.personAugustine, Dhanya
kaust.personHadjichristidis, Nikos
kaust.personGnanou, Yves
kaust.personFeng, Xiaoshuang
kaust.grant.numberBAS/1/1374-01-01
dc.date.accepted2020-01-19
refterms.dateFOA2021-01-30T00:00:00Z
dc.date.published-online2020-01-30
dc.date.published-print2020-02-11


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