Hydrophilic Stars, Amphiphilic Star Block Copolymers, and Miktoarm Stars with Degradable Polycarbonate Cores
Type
ArticleKAUST Department
Academic AffairsChemical Science Program
KAUST Catalysis Center (KCC)
Office of the VP
Physical Science and Engineering (PSE) Division
Polymer Synthesis Laboratory
KAUST Grant Number
BAS/1/1374-01-01Date
2020-01-30Online Publication Date
2020-01-30Print Publication Date
2020-02-11Embargo End Date
2021-01-30Submitted Date
2019-12-16Permanent link to this record
http://hdl.handle.net/10754/661351
Metadata
Show full item recordAbstract
A facile one-pot synthetic approach toward the realization of star polymers made of degradable carbonate cores is reported. The synthetic strategy involved triethylborane-activated anionic copolymerization of a difunctional epoxide with CO2 initiated by bis(triphenylphosphine)iminium chloride (PPNCl).Vinyl cyclohexene dioxide (VCD) was, thus, used as a difunctional cross-linker, and core compositions with 80−90% carbonate content were achieved. Poly(ethylene oxide) (PEO) arms were grown from these in-situ generated polycarbonate core anions to build a range of star polymers, including hydrophilic PEO stars and star-shaped block copolymers. Poly(propylene oxide) (PPO) precursors were used in a second approach as macroinitiators to form carbonate cores through the arm-first method; miktoarm stars having a large number of arms, both hydrophilic and hydrophobic, could be derived by this method. The carbonate cores of the synthesized stars were readily degraded through hydrolysis of the core carbonate linkages to yield PEO and PPO chains. Potential applications of these types of systems are manifold, especially for PEGbased drug delivery vehicles.Citation
Augustine, D., Hadjichristidis, N., Gnanou, Y., & Feng, X. (2020). Hydrophilic Stars, Amphiphilic Star Block Copolymers, and Miktoarm Stars with Degradable Polycarbonate Cores. Macromolecules. doi:10.1021/acs.macromol.9b02658Sponsors
This research work was supported by KAUST under baseline funding (BAS/1/1374-01-01).Publisher
American Chemical Society (ACS)Journal
MacromoleculesAdditional Links
https://pubs.acs.org/doi/10.1021/acs.macromol.9b02658ae974a485f413a2113503eed53cd6c53
10.1021/acs.macromol.9b02658