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    Characterization of a sponge microbiome using an integrative genome-centric approach

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    Name:
    Ircinia_ramosa_accepted.pdf
    Size:
    18.06Mb
    Format:
    PDF
    Description:
    Accepted manuscript
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    Type
    Article
    Authors
    Engelberts, J. Pamela
    Robbins, Steven J.
    de Goeij, Jasper M. cc
    Aranda, Manuel cc
    Bell, Sara C.
    Webster, Nicole S. cc
    KAUST Department
    Marine Science Program
    Red Sea Research Center (RSRC)
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2020-01-28
    Online Publication Date
    2020-01-28
    Print Publication Date
    2020-05
    Embargo End Date
    2020-07-28
    Submitted Date
    2019-07-22
    Permanent link to this record
    http://hdl.handle.net/10754/661330
    
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    Abstract
    Marine sponges often host diverse and species-specific communities of microorganisms that are critical for host health. Previous functional genomic investigations of the sponge microbiome have focused primarily on specific symbiont lineages, which frequently make up only a small fraction of the overall community. Here, we undertook genome-centric analysis of the symbiont community in the model species Ircinia ramosa and analyzed 259 unique, high-quality metagenomeassembled genomes (MAGs) that comprised 74% of the I. ramosa microbiome. Addition of these MAGs to genome trees containing all publicly available microbial sponge symbionts increased phylogenetic diversity by 32% within the archaea and 41% within the bacteria. Metabolic reconstruction of the MAGs showed extensive redundancy across taxa for pathways involved in carbon fixation, B-vitamin synthesis, taurine metabolism, sulfite oxidation, and most steps of nitrogen metabolism. Through the acquisition of all major taxa present within the I. ramosa microbiome, we were able to analyze the functional potential of a sponge-associated microbial community in unprecedented detail. Critical functions, such as carbon fixation, which had previously only been assigned to a restricted set of sponge-associated organisms, were actually spread across diverse symbiont taxa, whereas other essential pathways, such as ammonia oxidation, were confined to specific keystone taxa.
    Citation
    Engelberts, J. P., Robbins, S. J., de Goeij, J. M., Aranda, M., Bell, S. C., & Webster, N. S. (2020). Characterization of a sponge microbiome using an integrative genome-centric approach. The ISME Journal. doi:10.1038/s41396-020-0591-9
    Sponsors
    We acknowledge Andrea Severati and other staff at the Australian Institute of Marine Science SeaSim facility who assisted with sample collection and sponge husbandry.
    Publisher
    Springer Nature
    Journal
    The ISME Journal
    DOI
    10.1038/s41396-020-0591-9
    Additional Links
    http://www.nature.com/articles/s41396-020-0591-9
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41396-020-0591-9
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Red Sea Research Center (RSRC); Marine Science Program

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