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    Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells

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    Name:
    chin Phys B-2019-LY Liu.pdf
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    1.550Mb
    Format:
    PDF
    Description:
    Accepted manuscript
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    Type
    Article
    Authors
    Xiong, Ling
    Liu, Yanping
    Liu, Ruchuan
    Yuan, Wei
    Wang, Gao
    He, Yi
    Shuai, Jianwei
    Jiao, Yang
    Zhang, Xixiang cc
    Han, Weijing
    Qu, Junle
    Liu, Liyu
    KAUST Department
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Date
    2019-09-27
    Online Publication Date
    2019-09-27
    Print Publication Date
    2019-09
    Embargo End Date
    2020-08-14
    Permanent link to this record
    http://hdl.handle.net/10754/660984
    
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    Abstract
    Cancer cell motility and its heterogeneity play an important role in metastasis, which is responsible for death of 90% of cancer patients. Here, in combination with a microfluidic technique, single-cell tracking, and systematic motility analysis, we present a rapid and quantitative approach to judge the motility heterogeneity of breast cancer cells MDA-MB-231 and MCF-7 in a well-defined three-dimensional (3D) microenvironment with controllable conditions. Following this approach, identification of highly mobile active cells in a medium with epithelial growth factor will provide a practical tool for cell invasion and metastasis investigation of multiple cancer cell types, including primary cells. Further, this approach could potentially become a speedy (∼hours) and efficient tool for basic and clinical diagnosis.
    Citation
    Xiong, L., Liu, Y., Liu, R., Yuan, W., Wang, G., He, Y., … Liu, L. (2019). Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells. Chinese Physics B, 28(10), 108701. doi:10.1088/1674-1056/ab3af4
    Sponsors
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11674043 and 11604030), the Fundamental Research Funds for the Central Universities, China (Grant No. 2018CDJDWL0011), the Fundamental and Advanced Research Program of Chongqing, China (Grant No. cstc2018jcyjAX0338), and Arizona State University Start-up Funds, USA.
    Publisher
    IOP Publishing
    Journal
    Chinese Physics B
    DOI
    10.1088/1674-1056/ab3af4
    Additional Links
    https://iopscience.iop.org/article/10.1088/1674-1056/ab3af4
    ae974a485f413a2113503eed53cd6c53
    10.1088/1674-1056/ab3af4
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

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