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dc.contributor.authorMoussi, Khalil
dc.contributor.authorBu Khamsin, Abdullah
dc.contributor.authorHidalgo, Tania
dc.contributor.authorKosel, Jürgen
dc.date.accessioned2020-01-02T11:00:55Z
dc.date.available2020-01-02T11:00:55Z
dc.date.issued2019-11-27
dc.date.submitted2019-11-05
dc.identifier.citationMoussi, K., Bukhamsin, A., Hidalgo, T., & Kosel, J. (2019). Biocompatible 3D Printed Microneedles for Transdermal, Intradermal, and Percutaneous Applications. Advanced Engineering Materials, 1901358. doi:10.1002/adem.201901358
dc.identifier.issn1438-1656
dc.identifier.issn1527-2648
dc.identifier.doi10.1002/adem.201901358
dc.identifier.doi10.1002/adem.202070005
dc.identifier.urihttp://hdl.handle.net/10754/660925
dc.description.abstractMicroneedles (MNs) are playing an increasingly important role in biomedical applications, where minimally invasive methods are being developed that require imperceptible tissue penetration and drug delivery. To improve the integration of MNs in microelectromechanical devices, a high-resolution 3D printing technique is implemented. A reservoir with an array of hollow MNs is produced. The flow rate through the MNs is simulated and measured experimentally. The mechanical properties of the 3D printed material, such as elasticity modulus and yield strength, are investigated as functions of printing parameters, reaching maximum values of 1750.7 and 101.8 MPa, respectively. Analytical estimation of the MN buckling, fracture, and skin penetration forces is presented. Penetration tests of MNs into a skin-like material are conducted, where the piercing force ranges from 0.095 to 0.115 N, confirming sufficient stability of MNs. Furthermore, 200 and 400 μm-long MN arrays are used to successfully pierce and deliver into mouse skin with an average penetration depth of 100 and 180 μm, respectively. A biocompatibility assessment is performed, showing a high viability of HCT 116 cells cultured on top of the MN's material, making the developed MNs a very attractive solution for many biomedical applications.
dc.description.sponsorshipThis work was funded and supported by King Abdullah University of Science and Technology (KAUST). The authors thank Dr. Simona Spinelli, Francesco Rottoli, and Stefano Pietro Mandaglio from the Animal Research Core Lab (ARCL) at KAUST for their assistance with the mouse piercing experiment.
dc.publisherWiley
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/adem.201901358
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adem.201901358
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleBiocompatible 3D Printed Microneedles for Transdermal, Intradermal, and Percutaneous Applications
dc.typeArticle
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentElectrical Engineering
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentBiological and Environmental Science and Engineering Division (BESE), 4700 King Abdullah University of Science and Technology (KAUST), Thuwal, 23955, Kingdom of Saudi Arabia
dc.identifier.journalAdvanced Engineering Materials
dc.rights.embargodate2021-02-25
dc.eprint.versionPublisher's Version/PDF
dc.identifier.pages1901358
kaust.personMoussi, Khalil
kaust.personBu Khamsin, Abdullah
kaust.personHidalgo, Tania
kaust.personKosel, Jürgen
dc.date.accepted2019-11-27
dc.identifier.eid2-s2.0-85076771591
refterms.dateFOA2020-01-02T11:01:17Z
kaust.acknowledged.supportUnitAnimal Research Core Lab (ARCL) at KAUST
dc.date.published-online2020-02-24
dc.date.published-print2020-02


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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.