Hydride Transfer Enables the Nickel-Catalyzed ipso-Borylation and Silylation of Aldehydes
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Online Publication Date2019-12-09
Print Publication Date2020-01-07
Permanent link to this recordhttp://hdl.handle.net/10754/660921
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AbstractNickel-catalyzed ipso-borylations and silylations of aldehydes are described for the first time. The new functional-group interconversion protocol is characterized by its scalability, functional-group tolerance and wide substrate scope, including examples of late-stage functionalization of complex molecules. The key for the successful reaction outcome is the use of a ketone as a hydride acceptor that intercepts the nickel hydride to undergo a reductive pathway, thus allowing formation of the desired C−B and C−Si bonds.
CitationSrimontree, W., Guo, L., & Rueping, M. (2019). Hydride Transfer Enables the Nickel-Catalyzed ipso -Borylation and Silylation of Aldehydes. Chemistry – A European Journal. doi:10.1002/chem.201904842
SponsorsThis research was supported by King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research under award number URF/1/3030-01.
JournalChemistry - A European Journal
Except where otherwise noted, this item's license is described as Archived with thanks to Chemistry - A European Journal