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dc.contributor.authorohayon, David
dc.contributor.authorNikiforidis, Georgios
dc.contributor.authorSavva, Achilleas
dc.contributor.authorGiugni, Andrea
dc.contributor.authorWustoni, Shofarul
dc.contributor.authorPalanisamy, Tamilarasan
dc.contributor.authorChen, Xingxing
dc.contributor.authorMaria, Iuliana Petruta
dc.contributor.authorDi Fabrizio, Enzo M.
dc.contributor.authorDa Costa, Pedro M. F. J.
dc.contributor.authorMcCulloch, Iain
dc.contributor.authorInal, Sahika
dc.date.accessioned2019-12-30T06:46:30Z
dc.date.available2019-12-30T06:46:30Z
dc.date.issued2019-12-16
dc.identifier.citationOhayon, D., Nikiforidis, G., Savva, A., Giugni, A., Wustoni, S., Palanisamy, T., … Inal, S. (2019). Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer. Nature Materials. doi:10.1038/s41563-019-0556-4
dc.identifier.doi10.1038/s41563-019-0556-4
dc.identifier.urihttp://hdl.handle.net/10754/660864
dc.description.abstractA promising class of materials for applications that rely on electron transfer for signal generation are the n-type semiconducting polymers. Here we demonstrate the integration of an n-type conjugated polymer with a redox enzyme for the autonomous detection of glucose and power generation from bodily fluids. The reversible, mediator-free, miniaturized glucose sensor is an enzyme-coupled organic electrochemical transistor with a detection range of six orders of magnitude. This n-type polymer is also used as an anode and paired with a polymeric cathode in an enzymatic fuel cell to convert the chemical energy of glucose and oxygen into electrical power. The all-polymer biofuel cell shows a performance that scales with the glucose content in the solution and a stability that exceeds 30 days. Moreover, at physiologically relevant glucose concentrations and from fluids such as human saliva, it generates enough power to operate an organic electrochemical transistor, thus contributes to the technological advancement of self-powered micrometre-scale sensors and actuators that run on metabolites produced in the body.
dc.description.sponsorshipThe authors thank E. Bihar (KAUST) for her guidance during the experiments with saliva samples. The authors also thank J. Surgailis, J. I. de Oliveira Filho, L. B. Ospina and T. Cecilia-Hidalgo (KAUST) for spontaneous help. D.O., I.M. and S.I. gratefully acknowledge financial support from the KAUST Office of Sponsored Research (OSR) under Award no. OSR-2016-CRG5-3003. G.N. and S.I. acknowledge support from KAUST Sensors Initiative OSR Award no. REP/1/2719. Figures 1a and 4a were created by H. Hwang, scientific illustrator at KAUST.
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nature.com/articles/s41563-019-0556-4
dc.rightsArchived with thanks to Nature Materials
dc.titleBiofuel powered glucose detection in bodily fluids with an n-type conjugated polymer
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Solar Center (KSC)
dc.contributor.departmentMaterial Science and Engineering Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentWater Desalination and Reuse Research Center (WDRC)
dc.identifier.journalNature Materials
dc.rights.embargodate2020-06-16
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Chemistry and Centre for Plastic Electronics, Imperial College London, London, UK.
kaust.personOhayon, David
kaust.personNikiforidis, Georgios
kaust.personSavva, Achilleas
kaust.personGiugni, Andrea
kaust.personWustoni, Shofarul
kaust.personPalanisamy, Tamilarasan
kaust.personChen, Xingxing
kaust.personDi Fabrizio, Enzo M.
kaust.personDa Costa, Pedro M. F. J.
kaust.personMcCulloch, Iain
kaust.personInal, Sahika
kaust.grant.numberOSR-2016-CRG5-3003
kaust.acknowledged.supportUnitKAUST Office of Sponsored Research (OSR)
kaust.acknowledged.supportUnitscientific illustrator
dc.date.published-online2019-12-16
dc.date.published-print2020-04


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