Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer
Maria, Iuliana Petruta
Di Fabrizio, Enzo M.
Da Costa, Pedro M. F. J.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
KAUST Solar Center (KSC)
Material Science and Engineering Program
Physical Science and Engineering (PSE) Division
Water Desalination and Reuse Research Center (WDRC)
KAUST Grant NumberOSR-2016-CRG5-3003
Online Publication Date2019-12-16
Print Publication Date2020-04
Embargo End Date2020-06-16
Permanent link to this recordhttp://hdl.handle.net/10754/660864
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AbstractA promising class of materials for applications that rely on electron transfer for signal generation are the n-type semiconducting polymers. Here we demonstrate the integration of an n-type conjugated polymer with a redox enzyme for the autonomous detection of glucose and power generation from bodily fluids. The reversible, mediator-free, miniaturized glucose sensor is an enzyme-coupled organic electrochemical transistor with a detection range of six orders of magnitude. This n-type polymer is also used as an anode and paired with a polymeric cathode in an enzymatic fuel cell to convert the chemical energy of glucose and oxygen into electrical power. The all-polymer biofuel cell shows a performance that scales with the glucose content in the solution and a stability that exceeds 30 days. Moreover, at physiologically relevant glucose concentrations and from fluids such as human saliva, it generates enough power to operate an organic electrochemical transistor, thus contributes to the technological advancement of self-powered micrometre-scale sensors and actuators that run on metabolites produced in the body.
CitationOhayon, D., Nikiforidis, G., Savva, A., Giugni, A., Wustoni, S., Palanisamy, T., … Inal, S. (2019). Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer. Nature Materials. doi:10.1038/s41563-019-0556-4
SponsorsThe authors thank E. Bihar (KAUST) for her guidance during the experiments with saliva samples. The authors also thank J. Surgailis, J. I. de Oliveira Filho, L. B. Ospina and T. Cecilia-Hidalgo (KAUST) for spontaneous help. D.O., I.M. and S.I. gratefully acknowledge financial support from the KAUST Office of Sponsored Research (OSR) under Award no. OSR-2016-CRG5-3003. G.N. and S.I. acknowledge support from KAUST Sensors Initiative OSR Award no. REP/1/2719. Figures 1a and 4a were created by H. Hwang, scientific illustrator at KAUST.