Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite
AuthorsKeshk, Sherif M.A.S.
El-Zahhar, Adel A.
Alsulami, Qana A.
Al-Sehemi, Abdullah G.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Online Publication Date2019-11-27
Print Publication Date2020-02
Embargo End Date2020-11-27
Permanent link to this recordhttp://hdl.handle.net/10754/660593
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AbstractIn this study, a magnetically enhanced drug delivery composite was synthesized by co-precipitating magnetite nanoparticle (MNP) with 2,3-dialdehyde cellulose-6-phosphate (DACP) and investigated for ampyrone drug loading and controlled delivery. The magnetic core containing Fe3O4 was synthesized through the intramolecular Cannizzaro reaction during the in situ preparation of MNPs in the presence of sodium hydroxide solution, producing hydroxyl acid cellulose phosphate (HACP). The prepared magnetite nanocomposite MNP/HACP was characterized using FT-IR, SEM–EDX, XRD, TEM, VSM and TGA. The release profiles of ampyrone loaded on MNP/HACP showed a continuous release rate of more than 95% after 50 h, compared to the lower release rate of DACP, where only 60% of the loaded ampyrone was released after 50 h. These results show that MNP/HACP nanocomposites present an enhanced loading-release system with the potential to act as a magnetically enhanced drug delivery system.
CitationKeshk, S. M. A. S., El-Zahhar, A. A., Alsulami, Q. A., Jaremko, M., Bondock, S., & Heinze, T. (2019). Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite. Cellulose. doi:10.1007/s10570-019-02887-y
SponsorsThe authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through research groups program under Grant Number R.G.P. 1/19/40. Thomas Heinze acknowledged financially supported by the DFG-funded Collaborative Research Centre PolyTarget (SFB 1278, Project A02).