Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite
Type
ArticleAuthors
Keshk, Sherif M.A.S.
El-Zahhar, Adel A.
Alsulami, Qana A.
Al-Sehemi, Abdullah G.
Jaremko, Mariusz

Bondock, Samir
Heinze, Thomas
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Date
2019-11-27Online Publication Date
2019-11-27Print Publication Date
2020-02Embargo End Date
2020-11-27Permanent link to this record
http://hdl.handle.net/10754/660593
Metadata
Show full item recordAbstract
In this study, a magnetically enhanced drug delivery composite was synthesized by co-precipitating magnetite nanoparticle (MNP) with 2,3-dialdehyde cellulose-6-phosphate (DACP) and investigated for ampyrone drug loading and controlled delivery. The magnetic core containing Fe3O4 was synthesized through the intramolecular Cannizzaro reaction during the in situ preparation of MNPs in the presence of sodium hydroxide solution, producing hydroxyl acid cellulose phosphate (HACP). The prepared magnetite nanocomposite MNP/HACP was characterized using FT-IR, SEM–EDX, XRD, TEM, VSM and TGA. The release profiles of ampyrone loaded on MNP/HACP showed a continuous release rate of more than 95% after 50 h, compared to the lower release rate of DACP, where only 60% of the loaded ampyrone was released after 50 h. These results show that MNP/HACP nanocomposites present an enhanced loading-release system with the potential to act as a magnetically enhanced drug delivery system.Citation
Keshk, S. M. A. S., El-Zahhar, A. A., Alsulami, Q. A., Jaremko, M., Bondock, S., & Heinze, T. (2019). Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite. Cellulose. doi:10.1007/s10570-019-02887-ySponsors
The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through research groups program under Grant Number R.G.P. 1/19/40. Thomas Heinze acknowledged financially supported by the DFG-funded Collaborative Research Centre PolyTarget (SFB 1278, Project A02).Publisher
Springer Science and Business Media LLCJournal
CelluloseAdditional Links
http://link.springer.com/10.1007/s10570-019-02887-yae974a485f413a2113503eed53cd6c53
10.1007/s10570-019-02887-y