Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite

Abstract

In this study, a magnetically enhanced drug delivery composite was synthesized by co-precipitating magnetite nanoparticle (MNP) with 2,3-dialdehyde cellulose-6-phosphate (DACP) and investigated for ampyrone drug loading and controlled delivery. The magnetic core containing Fe3O4 was synthesized through the intramolecular Cannizzaro reaction during the in situ preparation of MNPs in the presence of sodium hydroxide solution, producing hydroxyl acid cellulose phosphate (HACP). The prepared magnetite nanocomposite MNP/HACP was characterized using FT-IR, SEM–EDX, XRD, TEM, VSM and TGA. The release profiles of ampyrone loaded on MNP/HACP showed a continuous release rate of more than 95% after 50 h, compared to the lower release rate of DACP, where only 60% of the loaded ampyrone was released after 50 h. These results show that MNP/HACP nanocomposites present an enhanced loading-release system with the potential to act as a magnetically enhanced drug delivery system.