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dc.contributor.authorJia, Kunpeng
dc.contributor.authorDickinson, Alexandra J.
dc.contributor.authorMi, Jianing
dc.contributor.authorCui, Guoxin
dc.contributor.authorXiao, Ting Ting
dc.contributor.authorKharbatia, Najeh M.
dc.contributor.authorGuo, Xiujie
dc.contributor.authorSugiono, Erli
dc.contributor.authorAranda, Manuel
dc.contributor.authorBlilou, Ikram
dc.contributor.authorRueping, Magnus
dc.contributor.authorBenfey, Philip N.
dc.contributor.authorAl-Babili, Salim
dc.date.accessioned2019-12-09T11:52:21Z
dc.date.available2019-12-09T11:52:21Z
dc.date.issued2019-11-27
dc.identifier.citationJia, K.-P., Dickinson, A. J., Mi, J., Cui, G., Xiao, T. T., Kharbatia, N. M., … Al-Babili, S. (2019). Anchorene is a carotenoid-derived regulatory metabolite required for anchor root formation in Arabidopsis. Science Advances, 5(11), eaaw6787. doi:10.1126/sciadv.aaw6787
dc.identifier.doi10.1126/sciadv.aaw6787
dc.identifier.urihttp://hdl.handle.net/10754/660474
dc.description.abstractAnchor roots (ANRs) arise at the root-shoot junction and are the least investigated type of <jats:italic>Arabidopsis</jats:italic> root. Here, we show that ANRs originate from pericycle cells in an auxin-dependent manner and a carotenogenic signal to emerge. By screening known and assumed carotenoid derivatives, we identified anchorene, a presumed carotenoid-derived dialdehyde (diapocarotenoid), as the specific signal needed for ANR formation. We demonstrate that anchorene is an <jats:italic>Arabidopsis</jats:italic> metabolite and that its exogenous application rescues the ANR phenotype in carotenoid-deficient plants and promotes the growth of normal seedlings. Nitrogen deficiency resulted in enhanced anchorene content and an increased number of ANRs, suggesting a role of this nutrient in determining anchorene content and ANR formation. Transcriptome analysis and treatment of auxin reporter lines indicate that anchorene triggers ANR formation by modulating auxin homeostasis. Together, our work reveals a growth regulator with potential application to agriculture and a new carotenoid-derived signaling molecule.
dc.description.sponsorshipWe thank B. Schaefer for valuable discussions and M. Khalid for technical support.
dc.description.sponsorshipThis work was supported by Baseline funding and the Research Grants Program-Round 4 (CRG4) from King Abdullah University of Science and Technology (KAUST) to S.A.-B., by the Arnold and Mabel Beckman Postdoctoral Fellowship to A.J.D., and by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation (through grant GBMF3405) to P.N.B.
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.relation.urlhttp://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aaw6787
dc.relation.urlhttps://advances.sciencemag.org/content/advances/5/11/eaaw6787.full.pdf
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleAnchorene is a carotenoid-derived regulatory metabolite required for anchor root formation in Arabidopsis
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentChemical Science Program
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentMarine Science Program
dc.contributor.departmentOrganics
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentPlant Science
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.identifier.journalScience Advances
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Biology and Howard Hughes Medical Institute, Duke University, Durham, NC 27708, USA.
dc.contributor.institutionRWTH Aachen University, Institute of Organic Chemistry, 52074 Aachen, Germany.
kaust.personJia, Kunpeng
kaust.personMi, Jianing
kaust.personCui, Guoxin
kaust.personXiao, Ting Ting
kaust.personKharbatia, Najeh M.
kaust.personGuo, Xiujie
kaust.personAranda, Manuel
kaust.personBlilou, Ikram
kaust.personRueping, Magnus
kaust.personAl-Babili, Salim
refterms.dateFOA2019-12-09T11:53:02Z
dc.date.published-online2019-11-27
dc.date.published-print2019-11


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This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.